Literature DB >> 12467566

RORalpha: an orphan nuclear receptor on a high-cholesterol diet.

Timothy M Willson.   

Abstract

A high-resolution X-ray crystal structure of the retinoic acid receptor-related orphan receptor (RORalpha; NR1F1), which reveals a molecule of cholesterol within the ligand binding pocket, is a breakthrough in functional analysis of this orphan nuclear receptor.

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Year:  2002        PMID： 12467566     DOI： 10.1016/s0969-2126(02)00916-4

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  2 in total

Review 1.  Orphan nuclear receptors in drug discovery.

Authors:  Yanhong Shi
Journal:  Drug Discov Today       Date:  2007-04-26       Impact factor: 7.851

2.  Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans.

Authors:  Sameer D Pant; Peter Karlskov-Mortensen; Mette J Jacobsen; Susanna Cirera; Lisette J A Kogelman; Camilla S Bruun; Thomas Mark; Claus B Jørgensen; Niels Grarup; Emil V R Appel; Ehm A A Galjatovic; Torben Hansen; Oluf Pedersen; Maryse Guerin; Thierry Huby; Philipppe Lesnik; Theo H E Meuwissen; Haja N Kadarmideen; Merete Fredholm
Journal:  PLoS One       Date:  2015-09-08       Impact factor: 3.240
  2 in total

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