Literature DB >> 12467249

Bacterial CpG-DNA licenses TLR9.

S Bauer1, H Wagner.   

Abstract

The family of Toll-like receptors (TLRs) plays an important role in the innate immune response to pathogens. TLRs sense pathogen associated molecular patterns (PAMP) and lead to the stimulation of immune cells. In man, so far ten members (TLR1-10) have been reported. This review focuses on TLR9 which is an essential component for the recognition of bacterial CpG-DNA. Expression of TLR9 and structural consideration as well as direct ligand interaction of TLR9 and CpG-DNA are discussed.

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Year:  2002        PMID： 12467249     DOI： 10.1007/978-3-642-59430-4_9

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  12 in total

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