Literature DB >> 12466416

Synaptically evoked GABA transporter currents in neocortical glia.

Gregory A Kinney1, William J Spain.   

Abstract

The presence, magnitude, and time course of GABA transporter currents were investigated in electrophysiologically characterized neocortical astrocytes in an in vitro slice preparation. On stimulation with a bipolar-tungsten stimulating electrode placed nearby, the majority of cells tested displayed long-lasting GABA transporter currents using both single and repetitive stimulation protocols. Using subtype-specific GABA transporter antagonists, long-lasting GABA transporter currents were identified in neocortical astrocytes that originated from at least two subtypes of GABA transporters: GAT-1 and GAT-2/3. These transporter currents displayed slow rise times and long decay times, contrasting the time course observed for glutamate transporter currents, and are indicative of a long extracellular time course of GABA as well as a role for glial GABA transporters during synaptic transmission.

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Year:  2002        PMID： 12466416     DOI： 10.1152/jn.00037.2002

Source DB:  PubMed          Journal:  J Neurophysiol        ISSN： 0022-3077            Impact factor:   2.714


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