OBJECTIVE: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. DESIGN: Interventional case report. METHODS: A full-thickness section of canaliculus was obtained during surgical repair. MAIN OUTCOME MEASURE: Histopathologic changes in the specimen. RESULTS: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. CONCLUSION: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.
OBJECTIVE: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. DESIGN: Interventional case report. METHODS: A full-thickness section of canaliculus was obtained during surgical repair. MAIN OUTCOME MEASURE: Histopathologic changes in the specimen. RESULTS: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. CONCLUSION:Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.
Authors: A Karamitsos; V Kokkas; A Goulas; P Paraskevopoulos; K Gougoulias; V Karampatakis; K Boboridis Journal: Hippokratia Date: 2013-04 Impact factor: 0.471