Literature DB >> 12465894

UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species.

Tsutomu Agatsuma1, Tsutomu Akama, Shinji Nara, Shigeki Matsumiya, Ryuichiro Nakai, Harumi Ogawa, Shizuo Otaki, Shun-Ichi Ikeda, Yutaka Saitoh, Yutaka Kanda.   

Abstract

[structure: see text] UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures and stereochemistry were elucidated by a combination of two-dimensional NMR and X-ray crystallographic analysis. UCS1025A showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and antiproliferative activity against human tumor cell lines.

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Year:  2002        PMID： 12465894     DOI： 10.1021/ol026923b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

Review 1.  Human telomerase inhibitors from microbial source.

Authors:  Kalarikkal Gopikrishnan Kiran; Muthusamy Palaniswamy; Jayaraman Angayarkanni
Journal:  World J Microbiol Biotechnol       Date:  2015-07-01       Impact factor: 3.312

2.  Studies on the microbial transformation of androst-1,4-dien-3,17-dione with Acremonium strictum.

Authors:  Mohammad Ali Faramarzi; Mojtaba Tabatabaei Yazdi; Hoda Jahandar; Mohsen Amini; Hamid Reza Monsef-Esfahani
Journal:  J Ind Microbiol Biotechnol       Date:  2006-05-31       Impact factor: 3.346

3.  Total Synthesis and Structural Revision of Antibiotic CJ-16,264.

Authors:  K C Nicolaou; Akshay A Shah; Henry Korman; Tabrez Khan; Lei Shi; Wisuttaya Worawalai; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-19       Impact factor: 15.336

4.  Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi.

Authors:  Man-Cheng Tang; Curt R Fischer; Jason V Chari; Dan Tan; Sundari Suresh; Angela Chu; Molly Miranda; Justin Smith; Zhuan Zhang; Neil K Garg; Robert P St Onge; Yi Tang
Journal:  J Am Chem Soc       Date:  2019-05-10       Impact factor: 15.419

5.  Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids.

Authors:  Li Li; Man-Cheng Tang; Shoubin Tang; Shushan Gao; Sameh Soliman; Leibniz Hang; Wei Xu; Tao Ye; Kenji Watanabe; Yi Tang
Journal:  J Am Chem Soc       Date:  2018-02-02       Impact factor: 15.419

6.  Codinaeopsin, an antimalarial fungal polyketide.

Authors:  Renee Kontnik; Jon Clardy
Journal:  Org Lett       Date:  2008-08-13       Impact factor: 6.005

7.  Enantioselective Total Synthesis of Antibiotic CJ-16,264, Synthesis and Biological Evaluation of Designed Analogues, and Discovery of Highly Potent and Simpler Antibacterial Agents.

Authors:  K C Nicolaou; Kiran Kumar Pulukuri; Stephan Rigol; Marek Buchman; Akshay A Shah; Nicholas Cen; Megan D McCurry; Kathryn Beabout; Yousif Shamoo
Journal:  J Am Chem Soc       Date:  2017-10-24       Impact factor: 15.419

8.  New Tetramic Acids Comprising of Decalin and Pyridones From Chaetomium olivaceum SD-80A With Antimicrobial Activity.

Authors:  Xinzhu Wang; Liya Zhao; Chao Liu; Jun Qi; Peipei Zhao; Zhaoming Liu; Chunlei Li; Yingying Hu; Xin Yin; Xin Liu; Zhixin Liao; Lixin Zhang; Xuekui Xia
Journal:  Front Microbiol       Date:  2020-01-15       Impact factor: 5.640

Review 9.  Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels-Alderases.

Authors:  Kenji Watanabe; Michio Sato; Hiroyuki Osada
Journal:  Fungal Biol Biotechnol       Date:  2022-04-29
  9 in total

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