OBJECTIVE: To assess potential differences in the phenotypic expression between familial and sporadic ankylosing spondylitis (AS). METHODS: Clinical data from the patient record forms were compared between 55 patients with AS from multicase families (i.e., families in which > or = 2 first-degree relatives have the disease) (familial AS) and 110 sex and age matched patients with AS who did not have a first-degree relative with the disease (sporadic AS). RESULTS: Between familial and sporadic AS no differences were found in age at disease onset, age at diagnosis, or prevalences of peripheral arthritis and acute anterior uveitis. CONCLUSION: Potential differences in genetic makeup are not reflected in differences in the phenotypic expression of familial and sporadic AS.
OBJECTIVE: To assess potential differences in the phenotypic expression between familial and sporadic ankylosing spondylitis (AS). METHODS: Clinical data from the patient record forms were compared between 55 patients with AS from multicase families (i.e., families in which > or = 2 first-degree relatives have the disease) (familial AS) and 110 sex and age matched patients with AS who did not have a first-degree relative with the disease (sporadic AS). RESULTS: Between familial and sporadic AS no differences were found in age at disease onset, age at diagnosis, or prevalences of peripheral arthritis and acute anterior uveitis. CONCLUSION: Potential differences in genetic makeup are not reflected in differences in the phenotypic expression of familial and sporadic AS.
Authors: Reeti Joshi; John D Reveille; Matthew A Brown; Michael H Weisman; Michael M Ward; Lianne S Gensler; B Paul Wordsworth; David M Evans; Shervin Assassi Journal: Arthritis Care Res (Hoboken) Date: 2012-05 Impact factor: 4.794
Authors: Hing Wo Tsui; Robert D Inman; Andrew D Paterson; John D Reveille; Florence W L Tsui Journal: Arthritis Res Ther Date: 2005-02-25 Impact factor: 5.156
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Authors: Augusta Ortolan; Miranda van Lunteren; Sofia Ramiro; Roberta Ramonda; Robert B M Landewé; Hanne Dagfinrud; Lennart T H Jacobsson; Désirée van der Heijde; Floris A van Gaalen Journal: Arthritis Res Ther Date: 2018-10-01 Impact factor: 5.156