Literature DB >> 12464351

Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001).

Ada Kolman1, Miroslav Chovanec, Siv Osterman-Golkar.   

Abstract

Ethylene oxide (EtO), propylene oxide (PO) and epichlorohydrin (ECH) are important industrial chemicals widely used as intermediates for various synthetic products. EtO and PO are also environmental pollutants. In this review we summarize data published during the period 1990-2001 concerning both the genotoxic and carcinogenic effects of these epoxides in humans. The use of DNA and hemoglobin adducts as biomarkers of exposure and the role of polymorphism, as well as confounding factors, are discussed. We have also included recent in vitro data comprising genotoxic effects induced by EtO, PO and ECH in mammalian cells. The uncertainties regarding cancer risk estimation still persist, in spite of the large database collected.

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Year:  2002        PMID： 12464351     DOI： 10.1016/s1383-5742(02)00067-4

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  18 in total

1.  Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA.

Authors:  Frederick J Lariviere; Adam G Newman; Megan L Watts; Sharonda Q Bradley; Justin E Juskewitch; Paul G Greenwood; Julie T Millard
Journal:  Mutat Res       Date:  2009-02-21       Impact factor: 2.433

2.  Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment.

Authors:  E Maria Donner; Brian A Wong; R Arden James; R Julian Preston
Journal:  Mutagenesis       Date:  2009-11-01       Impact factor: 3.000

3.  Polymerase bypass of N7-guanine monoadducts of cisplatin, diepoxybutane, and epichlorohydrin.

Authors:  Jiayu Ye; Caitlin R Farrington; Julie T Millard
Journal:  Mutat Res       Date:  2018-03-20       Impact factor: 2.433

4.  Mechanisms and kinetics of thiotepa and tepa hydrolysis: DFT study.

Authors:  Hedieh Torabifard; Alireza Fattahi
Journal:  J Mol Model       Date:  2012-02-14       Impact factor: 1.810

5.  Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells.

Authors:  Aley G Kalapila; Anthony E Pegg
Journal:  Mutat Res       Date:  2009-11-24       Impact factor: 2.433

6.  Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins.

Authors:  Aley G Kalapila; Natalia A Loktionova; Anthony E Pegg
Journal:  Environ Mol Mutagen       Date:  2009-07       Impact factor: 3.216

7.  DNA-protein crosslinks processed by nucleotide excision repair and homologous recombination with base and strand preference in E. coli model system.

Authors:  Qingming Fang
Journal:  Mutat Res       Date:  2013-03-15       Impact factor: 2.433

8.  DNA interstrand cross-linking by epichlorohydrin.

Authors:  Keith P Romano; Adam G Newman; Rami W Zahran; Julie T Millard
Journal:  Chem Res Toxicol       Date:  2007-04-19       Impact factor: 3.739

9.  Text mining for literature review and knowledge discovery in cancer risk assessment and research.

Authors:  Anna Korhonen; Diarmuid O Séaghdha; Ilona Silins; Lin Sun; Johan Högberg; Ulla Stenius
Journal:  PLoS One       Date:  2012-04-12       Impact factor: 3.240

10.  Alkyltransferase-like protein (eATL) prevents mismatch repair-mediated toxicity induced by O6-alkylguanine adducts in Escherichia coli.

Authors:  Gerard Mazon; Gaëlle Philippin; Jean Cadet; Didier Gasparutto; Mauro Modesti; Robert P Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-04       Impact factor: 11.205
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