OBJECTIVE: The aim of the present study is to assess information transmission between different cortical areas in schizophrenics by estimating the average cross mutual information (A-CMI) and to characterize the dynamical property of the cortical areas of schizophrenic patients from multi-channel EEG by establishing the auto mutual information (AMI). METHODS: We recorded the EEG from 16 electrodes in 10 schizophrenic patients and 10 age-matched normal controls. We estimated the slope of the AMI to evaluate the complexity of the EEG signal from one electrode and the A-CMI values of all 16x16 pairs of electrodes were calculated to investigate the information transmission of different cortical areas in schizophrenic patients. RESULTS: In T5 and C3 electrodes, the schizophrenic patients had lower complexity than normal controls. The schizophrenic patients had significantly higher interhemispheric and intrahemispheric A-CMI values than the normal controls. CONCLUSIONS: These results are consistent with previous findings that suggest left hemispheric hypotemporality and inter- and/or intra-hemispheric overconnectivity in schizophrenics. Our results of the left hemispheric hypotemporality and the increased interhemispheric information transmission in temporal lobe may support the hypothesis that the abnormal laterlization in temporal lobe are due to left temporal lobe deficit in schizophrenic patients.
OBJECTIVE: The aim of the present study is to assess information transmission between different cortical areas in schizophrenics by estimating the average cross mutual information (A-CMI) and to characterize the dynamical property of the cortical areas of schizophrenicpatients from multi-channel EEG by establishing the auto mutual information (AMI). METHODS: We recorded the EEG from 16 electrodes in 10 schizophrenicpatients and 10 age-matched normal controls. We estimated the slope of the AMI to evaluate the complexity of the EEG signal from one electrode and the A-CMI values of all 16x16 pairs of electrodes were calculated to investigate the information transmission of different cortical areas in schizophrenicpatients. RESULTS: In T5 and C3 electrodes, the schizophrenicpatients had lower complexity than normal controls. The schizophrenicpatients had significantly higher interhemispheric and intrahemispheric A-CMI values than the normal controls. CONCLUSIONS: These results are consistent with previous findings that suggest left hemispheric hypotemporality and inter- and/or intra-hemispheric overconnectivity in schizophrenics. Our results of the left hemispheric hypotemporality and the increased interhemispheric information transmission in temporal lobe may support the hypothesis that the abnormal laterlization in temporal lobe are due to left temporal lobe deficit in schizophrenicpatients.
Authors: David Santamarta; Roberto Hornero; Daniel Abásolo; Milton Martínez-Madrigal; Javier Fernández; Jose García-Cosamalón Journal: Childs Nerv Syst Date: 2010-08-03 Impact factor: 1.475
Authors: Balázs Hangya; Benedek T Tihanyi; László Entz; Dániel Fabó; Loránd Erőss; Lucia Wittner; Rita Jakus; Viktor Varga; Tamás F Freund; István Ulbert Journal: J Neurosci Date: 2011-06-15 Impact factor: 6.167