Literature DB >> 124622

Identification and turnover of glycosaminoglycans in rat kidneys.

D N Barry, J M Bowness.   

Abstract

The turnover of sulfate label in crude glycosaminoglycan fractions from rat kidney cortex, medulla, and papilla has been determined. Heparan sulfate, chondroitin sulfate, dermatan sulfate, and hyaluronate have been separated electrophoretically and their specific activities determined after injection of labeled sulfate or glucose. The half-lives of the sulfated glycosaminoglycans are within the ranges found for other organs and tissues, but hyaluornate has a somewhat faster turnover in the kidney than elsewhere.

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Year:  1975        PMID： 124622     DOI： 10.1139/o75-098

Source DB:  PubMed          Journal:  Can J Biochem        ISSN： 0008-4018


  6 in total

1.  Sulfate metabolism in the alloxan-diabetic rat: relationship of altered sulfate pools to proteoglycan sulfation in heart and other tissues.

Authors:  M J Spiro
Journal:  Diabetologia       Date:  1987-04       Impact factor: 10.122

2.  Isolation of glycosaminoglycans (heparan sulfate) from glomerular basement membranes.

Authors:  Y S Kanwar; M G Farquhar
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  Heparin inhibits mesangial cell proliferation in habu-venom-induced glomerular injury.

Authors:  A K Coffey; M J Karnovsky
Journal:  Am J Pathol       Date:  1985-08       Impact factor: 4.307

4.  Sulfated and nonsulfated glycosaminoglycans and glycopeptides are synthesized by kidney in vivo and incorporated into glomerular basement membranes.

Authors:  M C Lemkin; M G Farquhar
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

5.  Lysosomal storage of sulfated glycosaminoglycans in renal interstitial cells of rats treated with tilorone.

Authors:  R Lullmann-Rauch
Journal:  Cell Tissue Res       Date:  1987-12       Impact factor: 5.249

6.  Antibodies to basement membrane heparan sulfate proteoglycans bind to the laminae rarae of the glomerular basement membrane (GBM) and induce subepithelial GBM thickening.

Authors:  A Miettinen; J L Stow; S Mentone; M G Farquhar
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
  6 in total

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