| Literature DB >> 12461641 |
Y Açil1, I N G Springer, J G Prasse, J Hedderich, S Jepsen.
Abstract
Lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) are collagen cross-link residues. HP is present in most tissues, whereas LP is specific for bone and dentin. Based on the current literature there are certain indications that measurement of the concentrations of HP and LP in dentin may be a valuable tool to determine the individual age. The purpose of this investigation was to assess if the concentrations of LP and HP in dentin increase during lifetime. We have investigated 173 molars from 173 individuals (2 through 78 years of age, 31 primary and 142 secondary teeth) in the course of the present study. Levels of LP and HP were measured by HPLC and fluorescence detection. The results show that dentinal concentrations of HP and LP did not increase with age and varied between individuals of the same age and that determination of dentinal concentrations of HP and LP cannot be used to determine the individual age.Entities:
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Year: 2002 PMID： 12461641 DOI： 10.1007/s00414-002-0333-8
Source DB: PubMed Journal: Int J Legal Med ISSN： 0937-9827 Impact factor: 2.686