Literature DB >> 12461569

A blast from the past: clearance of apoptotic cells regulates immune responses.

John Savill1, Ian Dransfield, Chris Gregory, Chris Haslett.   

Abstract

Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future.

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Year:  2002        PMID： 12461569     DOI： 10.1038/nri957

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  537 in total

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9.  Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells.

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Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-21       Impact factor: 11.205

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