PURPOSE: To assess the potential use of spirometrically gated lung computed tomographic (CT) findings in the diagnosis of bronchiolitis obliterans syndrome after lung transplantation. MATERIALS AND METHODS: Forty-nine lung transplant recipients were examined at least 8 months after surgery with spirometrically gated thin-section CT of the lung. In addition to visual signs of small-airway disease at CT, mean lung attenuation and the SD were numerically determined and compared with the results of lung function testing at the time of the CT examination and 1 year later by using factorial analysis of variance. RESULTS: Mean lung attenuation was significantly lower in patients who developed bronchiolitis obliterans syndrome within 1 year after the CT study (-837 HU +/- 3) than in patients with persistent normal lung function (-812 HU +/- 3, P <.001). With an optimal threshold, sensitivity was 69%, specificity was 71%, and accuracy was 84%. Visual analysis did not significantly contribute to the prognostic power of CT. CONCLUSION: Spirometrically gated CT measurements of lung attenuation can be used to predict the onset of bronchiolitis obliterans syndrome after lung transplantation.
PURPOSE: To assess the potential use of spirometrically gated lung computed tomographic (CT) findings in the diagnosis of bronchiolitis obliterans syndrome after lung transplantation. MATERIALS AND METHODS: Forty-nine lung transplant recipients were examined at least 8 months after surgery with spirometrically gated thin-section CT of the lung. In addition to visual signs of small-airway disease at CT, mean lung attenuation and the SD were numerically determined and compared with the results of lung function testing at the time of the CT examination and 1 year later by using factorial analysis of variance. RESULTS: Mean lung attenuation was significantly lower in patients who developed bronchiolitis obliterans syndrome within 1 year after the CT study (-837 HU +/- 3) than in patients with persistent normal lung function (-812 HU +/- 3, P <.001). With an optimal threshold, sensitivity was 69%, specificity was 71%, and accuracy was 84%. Visual analysis did not significantly contribute to the prognostic power of CT. CONCLUSION: Spirometrically gated CT measurements of lung attenuation can be used to predict the onset of bronchiolitis obliterans syndrome after lung transplantation.
Authors: Lee Gazourian; Samuel Ash; Emily E K Meserve; Alejandro Diaz; Raul San Jose Estepar; Souheil Y El-Chemaly; Ivan O Rosas; Miguel Divo; Anne L Fuhlbrigge; Phillip C Camp; Vincent T Ho; Ami S Bhatt; Hilary J Goldberg; Lynette M Sholl; George R Washko Journal: Clin Transplant Date: 2017-04-12 Impact factor: 2.863
Authors: Lee Gazourian; Angela J Rogers; Ruby Ibanga; Gerald L Weinhouse; Victor Pinto-Plata; Jerome Ritz; Robert J Soiffer; Joseph H Antin; George R Washko; Rebecca M Baron; Vincent T Ho Journal: Am J Hematol Date: 2014-02-21 Impact factor: 10.047
Authors: Lee Gazourian; Anna Maria F Coronata; Angela J Rogers; Gerald L Weinhouse; Robert J Soiffer; Joseph H Antin; Jerome Ritz; Vincent T Ho; Rebecca M Baron; George R Washko Journal: Respir Med Date: 2012-11-26 Impact factor: 3.415
Authors: Pim A de Jong; Robin Vos; Geert M Verleden; Bart M Vanaudenaerde; Johny A Verschakelen Journal: Eur Radiol Date: 2011-07-27 Impact factor: 5.315