Literature DB >> 12460886

Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics.

Joshua R Merok1, Janice A Lansita, James R Tunstead, James L Sherley.   

Abstract

A long-standing intriguing hypothesis in cancer biology is that adult stem cells avoid mutations from DNA replication errors by a unique pattern of chromosome segregation. At each asymmetric cell division, adult stem cells have been postulated to selectively retain a set of chromosomes that contain old template DNA strands (i.e., "immortal DNA strands"). Using cultured cells that cycle with asymmetric cell kinetics, we confirmed both the existence of immortal DNA strands and the cosegregation of chromosomes that bear them. Our findings also lead us to propose a role for immortal DNA strands in tissue aging as well as cancer.

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Year:  2002        PMID： 12460886

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  50 in total

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2.  Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation.

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3.  Crypt dynamics and colorectal cancer: advances in mathematical modelling.

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4.  Cancer and the immortal strand hypothesis.

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8.  Microenvironmental modulation of asymmetric cell division in human lung cancer cells.

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9.  Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA.

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