Literature DB >> 1246030

Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride.

N Bodor, E Shek, T Higuchi.   

Abstract

A dihydropyridine-pyridine type redox pro-drug system was developed for delivering quaternary pyridinium salts through biological membranes. As a first application, the dihydropyridine derivative of N-methylpyridinium-2-carbaldoxime chloride (2-PAM) was synthesized using a reduction-addition-elimination sequence. The dihydro-2-PAM obtained has all the required properties for an effective transport through lipoidal barriers and it reverts easily back to 2-PAM as a result of a chemical or enzymatic oxidation process.

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Year:  1976        PMID： 1246030     DOI： 10.1021/jm00223a017

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  10 in total

1.  Amine prodrugs which utilize hydroxy amide lactonization. I. A potential redox-sensitive amide prodrug.

Authors:  K L Amsberry; R T Borchardt
Journal:  Pharm Res       Date:  1991-03       Impact factor: 4.200

Review 2.  Prodrugs. Do they have advantages in clinical practice?

Authors:  V J Stella; W N Charman; V H Naringrekar
Journal:  Drugs       Date:  1985-05       Impact factor: 9.546

3.  Proceedings of the British Pharmacological Society. 17th-19th December, 1979: University of London (Institute of Education).

Authors: 
Journal:  Br J Pharmacol       Date:  1980-06       Impact factor: 8.739

Review 4.  Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase.

Authors:  Andrew J Franjesevic; Sydney B Sillart; Jeremy M Beck; Shubham Vyas; Christopher S Callam; Christopher M Hadad
Journal:  Chemistry       Date:  2019-02-13       Impact factor: 5.236

5.  Pro-2-PAM therapy for central and peripheral cholinesterases.

Authors:  James C Demar; Edward D Clarkson; Ruthie H Ratcliffe; Amy J Campbell; Sonia G Thangavelu; Christine A Herdman; Haim Leader; Susan M Schulz; Elizabeth Marek; Marie A Medynets; Therese C Ku; Sarah A Evans; Farhat A Khan; Roberta R Owens; Madhusoodana P Nambiar; Richard K Gordon
Journal:  Chem Biol Interact       Date:  2010-02-13       Impact factor: 5.192

6.  New therapeutic approaches and novel alternatives for organophosphate toxicity.

Authors:  Francine S Katz; Stevan Pecic; Laura Schneider; Zhengxiang Zhu; Ashley Hastings; Michal Luzac; Joanne Macdonald; Donald W Landry; Milan N Stojanovic
Journal:  Toxicol Lett       Date:  2018-03-31       Impact factor: 4.372

Review 7.  Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes.

Authors:  Janice E Chambers; Mary B Dail; Edward C Meek
Journal:  Neuropharmacology       Date:  2020-06-13       Impact factor: 5.250

Review 8.  Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives.

Authors:  Sherif A Gaballa; Uday B Kompella; Omar Elgarhy; Ali M Alqahtani; Barbara Pierscionek; Raid G Alany; Hamdy Abdelkader
Journal:  Drug Deliv Transl Res       Date:  2021-06       Impact factor: 4.617

9.  Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate.

Authors:  Timothy L Comstock; Heleen H Decory
Journal:  Int J Inflam       Date:  2012-03-28

Review 10.  Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.

Authors:  Janice E Chambers; Edward C Meek
Journal:  Ann N Y Acad Sci       Date:  2020-04-21       Impact factor: 6.499
  10 in total

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