Literature DB >> 1246029

On the structure of medicinal chemistry.

C Hansch.   

Abstract

The great advances in biochemistry and molecular biology, the development of physical organic chemistry, and the availability of large computers are creating opportunities for restructuring medicinal chemistry. The enormous volume of scientific results relevant to medicinal chemistry which appear with each new round of the journals forces us to make greater efforts to bring the information together in more meaningful patterns. The QSAR paradigm redirects our thinking about structuring medicinal chemistry.

Mesh:

Year:  1976        PMID: 1246029     DOI: 10.1021/jm00223a001

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  9 in total

1.  Usefulness of graphical invariants in quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type.

Authors:  Manish C Bagchi; Bhim C Maiti; Denise Mills; Subhash C Basak
Journal:  J Mol Model       Date:  2003-12-23       Impact factor: 1.810

Review 2.  Neural networks as robust tools in drug lead discovery and development.

Authors:  David A Winkler
Journal:  Mol Biotechnol       Date:  2004-06       Impact factor: 2.695

3.  On an aspect of calculated molecular descriptors in QSAR studies of quinolone antibacterials.

Authors:  Payel Ghosh; Megha Thanadath; Manish C Bagchi
Journal:  Mol Divers       Date:  2006-08-02       Impact factor: 2.943

Review 4.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

Review 5.  How medicinal chemists learned about log P.

Authors:  Yvonne Connolly Martin
Journal:  J Comput Aided Mol Des       Date:  2018-07-17       Impact factor: 3.686

6.  Distance geometry analysis of ligand binding to drug receptor sites.

Authors:  G M Donné-Op den Kelder
Journal:  J Comput Aided Mol Des       Date:  1987-10       Impact factor: 3.686

Review 7.  Quantitative structure-activity relationships of insecticides and plant growth regulators: comparative studies toward understanding the molecular mechanism of action.

Authors:  H Iwamura; K Nishimura; T Fujita
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031

Review 8.  Partitioning and lipophilicity in quantitative structure-activity relationships.

Authors:  J C Dearden
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031

9.  Diverse models for anti-HIV activity of purine nucleoside analogs.

Authors:  Naveen Khatri; Viney Lather; A K Madan
Journal:  Chem Cent J       Date:  2015-05-23       Impact factor: 4.215

  9 in total

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