| Literature DB >> 12459523 |
Paola Borgiani1, Laura Vallo, Maria Rosaria D'Apice, Emiliano Giardina, Sabina Pucci, Francesca Capon, Steven Nisticò, Sergio Chimenti, Francesco Pallone, Giuseppe Novelli.
Abstract
Psoriasis is a chronic inflammatory skin disorder showing multifactorial inheritance. Linkage studies have mapped disease susceptibility loci to several genomic regions, including the chromosome 16 interval that contains the CARD15/NOD2 gene. CARD15 has been involved in Crohn's Disease (CD) susceptibility and it has been hypothesised that it may also contribute to the pathogenesis of psoriasis. To test this hypothesis we studied the distribution of 3 CARD15 SNPs in an Italian case-control data set. We failed to observe any significant difference between patients and controls, thereby excluding the presence of a strong genetic association between CARD15 gene polymorphisms and psoriasis, in the Italian population.Entities:
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Year: 2002 PMID： 12459523
Source DB: PubMed Journal: Eur J Dermatol ISSN： 1167-1122 Impact factor: 3.328