Literature DB >> 12459339

Short-term and long-term modulation of gene expression by antisense therapeutics.

Peter Sazani1, Marla M Vacek, Ryszard Kole.   

Abstract

To achieve effective modulation of gene expression by antisense oligonucleotides, novel oligonucleotide chemistries that do not promote RNase H degradation of target RNA are needed. In addition to short-term oligonucleotide effects, long-term gene regulation can be accomplished by intracellularly expressed antisense RNAs delivered by viral vectors.

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Year:  2002        PMID： 12459339     DOI： 10.1016/s0958-1669(02)00366-x

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  7 in total

Review 1.  Strategies for identifying genes that play a role in spinal cord regeneration.

Authors:  M Wintzer; M Mladinic; D Lazarevic; C Casseler; A Cattaneo; J Nicholls
Journal:  J Anat       Date:  2004-01       Impact factor: 2.610

Review 2.  Antisense makes sense in engineered regenerative medicine.

Authors:  Yongchang Yao; Chunming Wang; Rohan R Varshney; Dong-An Wang
Journal:  Pharm Res       Date:  2008-11-18       Impact factor: 4.200

3.  Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor.

Authors:  Hippokratis Kiaris; Ioulia Chatzistamou; Andrew V Schally; Gabor Halmos; Jozsef L Varga; Helen Koutselini; Anastasios Kalofoutis
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-16       Impact factor: 11.205

4.  Effective delivery of antisense peptide nucleic acid oligomers into cells by anthrax protective antigen.

Authors:  Daniel G Wright; Ying Zhang; John R Murphy
Journal:  Biochem Biophys Res Commun       Date:  2008-09-05       Impact factor: 3.575

5.  Variables and strategies in development of therapeutic post-transcriptional gene silencing agents.

Authors:  Jack M Sullivan; Edwin H Yau; Tiffany A Kolniak; Lowell G Sheflin; R Thomas Taggart; Heba E Abdelmaksoud
Journal:  J Ophthalmol       Date:  2011-06-30       Impact factor: 1.909

Review 6.  Alternative splicing: an important mechanism for myometrial gene regulation that can be manipulated to target specific genes associated with preterm labour.

Authors:  Alison Jane Tyson-Capper
Journal:  BMC Pregnancy Childbirth       Date:  2007-06-01       Impact factor: 3.007

7.  A non-covalent peptide-based carrier for in vivo delivery of DNA mimics.

Authors:  May C Morris; Edwige Gros; Gudrun Aldrian-Herrada; Michael Choob; John Archdeacon; Frederic Heitz; Gilles Divita
Journal:  Nucleic Acids Res       Date:  2007-03-05       Impact factor: 16.971
  7 in total

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