| Literature DB >> 12459010 |
Sven Guenther1, Jan Balzarini, Erik De Clercq, Vasu Nair.
Abstract
(E)-5-(2-Bromovinyl)isodideoxyuridine (BVisoDDU), synthesized on the basis of molecular modeling, is selectively active against HSV-1 (three different strains) but inactive against HSV-2. Unlike BVDU, BVisoDDU is completely resistant to cleavage by thymidine phosphorylase. BVisoDDU is also the first nucleoside analogue lacking OH groups at both the 2'- and 3'-position that shows pronounced activity against HSV-1 replication.Entities:
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Year: 2002 PMID： 12459010 DOI： 10.1021/jm025569k
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446