Literature DB >> 12458837

From taxol to Taxol: the changing identities and ownership of an anti-cancer drug.

Vivien Walsh1, Jordan Goodman.   

Abstract

This paper analyzes the emergence and evolution of taxol, the world's bestselling anti-cancer drug. Over the years taxol has changed its identity, its status as property, and its association with different places (from the old-growth forests of Washington State to the government agencies of Washington, D.C., to laboratories in France). Taxol is not only a profitable pharmaceutical commodity and a substance injected into women with breast and/or ovarian cancer; it is also a natural product found in the bark of Taxus brevifolia (the Pacific yew, which is native to the North American Pacific Northwest) and a chemical substance that was discovered and brought to the point of commercial production in the public sector. We explore its role in several controversies: the destruction of old-growth forests, public participation in policy making, and the privatization of intellectual property and its effect on the price of drugs.

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Year:  2002        PMID: 12458837     DOI: 10.1080/01459740214074

Source DB:  PubMed          Journal:  Med Anthropol        ISSN: 0145-9740


  14 in total

1.  Taxol biosynthesis and molecular genetics.

Authors:  Rodney Croteau; Raymond E B Ketchum; Robert M Long; Rüdiger Kaspera; Mark R Wildung
Journal:  Phytochem Rev       Date:  2006-02       Impact factor: 5.374

2.  Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles.

Authors:  Lauren M Zasadil; Kristen A Andersen; Dabin Yeum; Gabrielle B Rocque; Lee G Wilke; Amye J Tevaarwerk; Ronald T Raines; Mark E Burkard; Beth A Weaver
Journal:  Sci Transl Med       Date:  2014-03-26       Impact factor: 17.956

Review 3.  The shape of things to come: structural and synthetic studies of taxol and related compounds.

Authors:  David G I Kingston
Journal:  Phytochemistry       Date:  2006-12-20       Impact factor: 4.072

Review 4.  Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer.

Authors:  Nirmala Chandralega Kampan; Mutsa Tatenda Madondo; Orla M McNally; Michael Quinn; Magdalena Plebanski
Journal:  Biomed Res Int       Date:  2015-06-07       Impact factor: 3.411

Review 5.  A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs.

Authors:  C Khanna; M Rosenberg; D M Vail
Journal:  J Vet Intern Med       Date:  2015 Jul-Aug       Impact factor: 3.333

6.  Efficacies of the new paclitaxel-eluting Coroflex Please stent in percutaneous coronary intervention; comparison of efficacy between Coroflex Please and Taxus (ECO-PLEASANT) trial: study rationale and design.

Authors:  Jae-Bin Seo; Hui-Kyung Jeon; Kyung-Woo Park; Jong-Seon Park; Jang-Ho Bae; Sang-Wook Kim; Keon-Woong Moon; Jae-Woong Choi; Sang-Gon Lee; Woo-Young Chung; Tae-Jin Youn; Soo-Joong Kim; Doo-Il Kim; Byung-Ok Kim; Min-Su Hyon; Keum-Soo Park; Tae-Joon Cha; Hweung-Kon Hwang; Seung-Ho Hur; Hyo-Soo Kim
Journal:  Trials       Date:  2009-10-23       Impact factor: 2.279

7.  Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts.

Authors:  Simone Pacioni; Quintino Giorgio D'Alessandris; Stefano Giannetti; Liliana Morgante; Ivana De Pascalis; Valentina Coccè; Arianna Bonomi; Luisa Pascucci; Giulio Alessandri; Augusto Pessina; Maria Laura Falchetti; Roberto Pallini
Journal:  Stem Cell Res Ther       Date:  2015-10-06       Impact factor: 6.832

8.  How Taxol/paclitaxel kills cancer cells.

Authors:  Beth A Weaver
Journal:  Mol Biol Cell       Date:  2014-09-15       Impact factor: 4.138

9.  The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.

Authors:  David G I Kingston; James P Snyder
Journal:  Acc Chem Res       Date:  2014-07-23       Impact factor: 22.384

Review 10.  Paclitaxel's Mechanistic and Clinical Effects on Breast Cancer.

Authors:  Tala M Abu Samaan; Marek Samec; Alena Liskova; Peter Kubatka; Dietrich Büsselberg
Journal:  Biomolecules       Date:  2019-11-27
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