Effect of VHa locus allotype-suppression on the expression of closely linked VHx, VHy, and Cmun genes in heterozygous rabbits.

Injection of a1x-y-n81/a2x32y33n82 heterozygous rabbit at birth with anti-a2 allotype antiserum suppresses the production of the VHa2 gene product a2 Ig as well as the expression of the closely linked Cmun gene product n82 but not of the closely linked VHx and VHy gene products x32 and x33. This effect is related to the appearance of a2 and n82 on the same IgM molecules whereas a2, x32, and y33 appear on different Ig molecules.