Literature DB >> 1245582

Gas chromatographic method for the determination of nomifensine in human plasma.

L Vereczkey, G Bianchetti, V Rovei, A Frigerio.   

Abstract

An analytical method based on solvent extraction, formation of a fluorinated derivative and quantitation by gas-liquid chromatography using an electron capture detector has been developed for the determination of nomifensine in biological fluids. The specificity (controlled by mass spectrometry) and the sensitivity appear to be satisfactory for drug level measurements in human body fluids. Its relative simplicity in fact permits its use in serial analysis.

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Year:  1976        PMID: 1245582     DOI: 10.1016/s0021-9673(00)89916-1

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

1.  Determination of nomifensine by a sensitive radioimmunoassay.

Authors:  W Heptner; M J Badian; S Baudner; O E Christ; H M Fraser; W Rupp; K E Weimer; H Wissmann
Journal:  Br J Clin Pharmacol       Date:  1977       Impact factor: 4.335

2.  A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques.

Authors:  J Chamberlain; H M Hill
Journal:  Br J Clin Pharmacol       Date:  1977       Impact factor: 4.335

3.  Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1979-07       Impact factor: 9.546

4.  First-pass metabolism of nomifensine in dogs.

Authors:  R Lindberg; R Sellman; E Iisalo
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1985 Jan-Mar       Impact factor: 2.441

  4 in total

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