Literature DB >> 12454647

Characterizing the physical genome.

Jonathan R Pollack1, Vishwanath R Iyer.   

Abstract

The genome of an organism is a dynamic physical entity, comprising genomic DNA bound to many different proteins and organized into chromosomes. A thorough characterization of the physical genome is relevant to our understanding of processes such as the regulation of gene expression, DNA replication and repair, recombination, chromosome segregation, epigenetic inheritance and genomic instability. Methods based on microarrays are beginning to provide a detailed picture of this physical genome, and they complement the genome-wide studies of mRNA expression profiling that have previously been so successful.

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Year:  2002        PMID： 12454647     DOI： 10.1038/ng1035

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

1.  Genomic imbalances in mental retardation.

Authors:  M Kriek; S J White; M C Bouma; H G Dauwerse; K B M Hansson; J V Nijhuis; B Bakker; G-J B van Ommen; J T den Dunnen; M H Breuning
Journal:  J Med Genet       Date:  2004-04       Impact factor: 6.318

2.  Singular value decomposition of genome-scale mRNA lengths distribution reveals asymmetry in RNA gel electrophoresis band broadening.

Authors:  Orly Alter; Gene H Golub
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-28       Impact factor: 11.205

Review 3.  The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome.

Authors:  R Romero; J Espinoza; F Gotsch; J P Kusanovic; L A Friel; O Erez; S Mazaki-Tovi; N G Than; S Hassan; G Tromp
Journal:  BJOG       Date:  2006-12       Impact factor: 6.531

4.  Discovery of principles of nature from mathematical modeling of DNA microarray data.

Authors:  Orly Alter
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-23       Impact factor: 11.205

5.  Genome-wide analysis of chromatin status using tiling microarrays.

Authors:  Sushma Shivaswamy; Vishwanath R Iyer
Journal:  Methods       Date:  2007-03       Impact factor: 3.608

Review 6.  Uncovering transcription factor modules using one- and three-dimensional analyses.

Authors:  Xun Lan; Peggy J Farnham; Victor X Jin
Journal:  J Biol Chem       Date:  2012-09-05       Impact factor: 5.157

7.  Development of a DNA-labeling system for array-based comparative genomic hybridization.

Authors:  Pauline T Lieu; Peter Jozsi; Patrick Gilles; Todd Peterson
Journal:  J Biomol Tech       Date:  2005-06

8.  The role of rare structural variants in the genetics of autism spectrum disorders.

Authors:  M Kusenda; J Sebat
Journal:  Cytogenet Genome Res       Date:  2009-03-11       Impact factor: 1.636

9.  Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles.

Authors:  Jonghwan Kim; Vishwanath R Iyer
Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272

10.  Definition of a critical region on chromosome 18 for congenital aural atresia by arrayCGH.

Authors:  Joris A Veltman; Yvonne Jonkers; Inge Nuijten; Irene Janssen; Walter van der Vliet; Erik Huys; Joris Vermeesch; Griet Van Buggenhout; Jean-Pierre Fryns; Ronald Admiraal; Paulien Terhal; Didier Lacombe; Ad Geurts van Kessel; Dominique Smeets; Eric F P M Schoenmakers; Conny M van Ravenswaaij-Arts
Journal:  Am J Hum Genet       Date:  2003-05-09       Impact factor: 11.025
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