| Literature DB >> 12453596 |
Héric Valette1, Frédéric Dollé, Michel Bottlaender, Françoise Hinnen, Daniel Marzin.
Abstract
The potential mutagenic properties (micronucleus and the Ames tests) of fluoro-A-85380 (2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine) were evaluated as a mandatory pre-clinical step. No statistically significant increase in the frequency of micronucleated polychromatic erythrocytes was found in animals treated at any dose tested. No biologically significant increase in the mean number of revertants was noted in all the Salmonella typhimurium strains tested with fluoro-A-85380. Therefore, fluoro-A-85380 demonstrated no mutagenic properties using these two tests.Entities:
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Year: 2002 PMID： 12453596 DOI： 10.1016/s0969-8051(02)00331-1
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408