Literature DB >> 1245234

Mechanism of protection against the delayed neurotoxic effects of organophosphorus esters.

M K Johnson.   

Abstract

Delayed neurotoxic effects arise as a result of two distinct biochemical events: 1) inhibiton of neurotoxic esterase, and 2) 'aging' of inhibited enzyme. Protective agents undergo reaction 1 but cannot undergo 2. Reaction 2 may interfere with a normal physiological control mechanism.

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Year:  1976        PMID： 1245234

Source DB:  PubMed          Journal:  Fed Proc        ISSN： 0014-9446


  4 in total

1.  Neurotoxic esterase. Identification of two isoenzymes in hen brain.

Authors:  J M Chemnitius; K H Haselmeyer; R Zech
Journal:  Arch Toxicol       Date:  1983-07       Impact factor: 5.153

2.  Rapid aging of neurotoxic esterase after inhibition by di-isopropyl phosphorofluoridate.

Authors:  B Clothier; M K Johnson
Journal:  Biochem J       Date:  1979-02-01       Impact factor: 3.857

3.  Ecotoxicology of phenylphosphonothioates.

Authors:  B M Francis; L G Hansen; T R Fukuto; P Y Lu; R L Metcalf
Journal:  Environ Health Perspect       Date:  1980-06       Impact factor: 9.031

Review 4.  Environmental chemicals and nervous system dysfunction.

Authors:  T Damstra
Journal:  Yale J Biol Med       Date:  1978 Jul-Aug
  4 in total

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