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Literature DB >> 12451493

Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878.

Pattama Pittayakhajonwut¹, Man Theerasilp, Palangpon Kongsaeree, Amporn Rungrod, Morakot Tanticharoen, Yodhathai Thebtaranonth.

Abstract

A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC 50 values of 2.0 and 1.6 microg/mL, respectively.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2002 PMID： 12451493 DOI： 10.1055/s-2002-35653

Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352

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Cited

5 in total

1. Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship.

Authors: Christopher Y Bemis; Chad N Ungarean; Alexander S Shved; Cooper S Jamieson; Taehwan Hwang; Ken S Lee; K N Houk; David Sarlah
Journal: J Am Chem Soc Date: 2021-04-07 Impact factor: 16.383

2. Sea foam as a source of fungal inoculum for the isolation of biologically active natural products.

Authors: David P Overy; Fabrice Berrue; Hebelin Correa; Novriyandi Hanif; Kathryn Hay; Martin Lanteigne; Kathrine Mquilian; Stephanie Duffy; Patricia Boland; Ramesh Jagannathan; Gavin S Carr; Marieke Vansteeland; Russell G Kerr
Journal: Mycology Date: 2014-07-09

Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878.

1. Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship.

2. Sea foam as a source of fungal inoculum for the isolation of biologically active natural products.

3. Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12.

4. Humulane-Type Macrocyclic Sesquiterpenoids From the Endophytic Fungus Penicillium sp. of Carica papaya.

Review 5. Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids.