OBJECTIVE: To determine the feasibility and usefulness of ictal magnetoencephalography (MEG) recordings in the presurgical evaluation of patients with epilepsy. METHODS: Twenty patients with frequent or predictable seizures were studied with the intent to capture seizures using a large array single-probe 37-channel or dual-probe 74-channel biomagnetometer. RESULTS: Successful ictal MEG recordings were made in 6 of 20 patients with neocortical epilepsy. In one other patient, a seizure was captured but movement artifact made MEG recordings impossible. As determined by invasive EEG recording and postsurgical outcome, ictal MEG provided localizing information that was superior to interictal MEG in three of the six patients. Localization of ictal onset by MEG was at least equivalent to invasive EEG in five of the six patients, and was superior in two patients as determined by postsurgical outcome. CONCLUSION: Larger studies are necessary to confirm that ictal MEG recordings in patients with frequent or easily provoked neocortical seizures can contribute localizing information equivalent or superior to invasive EEG recording.
OBJECTIVE: To determine the feasibility and usefulness of ictal magnetoencephalography (MEG) recordings in the presurgical evaluation of patients with epilepsy. METHODS: Twenty patients with frequent or predictable seizures were studied with the intent to capture seizures using a large array single-probe 37-channel or dual-probe 74-channel biomagnetometer. RESULTS: Successful ictal MEG recordings were made in 6 of 20 patients with neocortical epilepsy. In one other patient, a seizure was captured but movement artifact made MEG recordings impossible. As determined by invasive EEG recording and postsurgical outcome, ictal MEG provided localizing information that was superior to interictal MEG in three of the six patients. Localization of ictal onset by MEG was at least equivalent to invasive EEG in five of the six patients, and was superior in two patients as determined by postsurgical outcome. CONCLUSION: Larger studies are necessary to confirm that ictal MEG recordings in patients with frequent or easily provoked neocortical seizures can contribute localizing information equivalent or superior to invasive EEG recording.
Authors: Rafeed Alkawadri; Richard C Burgess; Yosuke Kakisaka; John C Mosher; Andreas V Alexopoulos Journal: JAMA Neurol Date: 2018-10-01 Impact factor: 18.302
Authors: Yosuke Kakisaka; Zhong I Wang; John C Mosher; Anne-Sophie Dubarry; Andreas V Alexopoulos; Rei Enatsu; Prakash Kotagal; Richard C Burgess Journal: Epilepsy Res Date: 2012-04-14 Impact factor: 3.045
Authors: Naoaki Tanaka; Andrew J Cole; Deidre von Pechmann; Daniel G Wakeman; Matti S Hämäläinen; Hesheng Liu; Joseph R Madsen; Blaise F Bourgeois; Steven M Stufflebeam Journal: Epilepsy Res Date: 2009-04-24 Impact factor: 3.045
Authors: Rafeed Alkawadri; Balu Krishnan; Yosuke Kakisaka; Dileep Nair; John C Mosher; Richard C Burgess; Andreas V Alexopoulos Journal: Clin Neurophysiol Date: 2013-05-02 Impact factor: 3.708