Literature DB >> 12450770

Endometriosis is sustained by tumour necrosis factor-alpha.

D W Bullimore1.   

Abstract

Endometriosis is a common gynaecological disorder causing pain, infertility, and emotional distress. Evidence presented here suggests that abnormal production of tumour necrosis factor-alpha (TNF-alpha) is required for the establishment and maintenance of endometriosis and also is responsible for the associated infertility through its effect on sperm motility and function and oocyte development. Infliximab, which blocks TNF-alpha function, could be used in the treatment of endometriosis to reverse the above effects.

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Year:  2003        PMID： 12450770     DOI： 10.1016/s0306-9877(02)00336-5

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  6 in total

1.  Elevated peritoneal fluid TNF-α incites ovarian early growth response factor 1 expression and downstream protease mediators: a correlation with ovulatory dysfunction in endometriosis.

Authors:  Julie A Birt; Henda Nabli; Julie A Stilley; Emma A Windham; Shellaine R Frazier; Kathy L Sharpe-Timms
Journal:  Reprod Sci       Date:  2013-02-20       Impact factor: 3.060

Review 2.  Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†.

Authors:  Abdelrahman AlAshqar; Lauren Reschke; Gregory W Kirschen; Mostafa A Borahay
Journal:  Biol Reprod       Date:  2021-07-02       Impact factor: 4.285

3.  The diagnostic role of cervico-vaginal fluid interleukins-1α in endometriosis: A case-control study.

Authors:  Farahnaz Mardanian; Zahra Sheikh-Soleimani
Journal:  J Res Med Sci       Date:  2014-12       Impact factor: 1.852

Review 4.  "Iron triangle" of regulating the uterine microecology: Endometrial microbiota, immunity and endometrium.

Authors:  Na Zhu; Xuyan Yang; Qiao Liu; Yahui Chen; Xiaolan Wang; Huanhuan Li; Hong Gao
Journal:  Front Immunol       Date:  2022-08-09       Impact factor: 8.786

5.  Anti-TNF-alpha treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial.

Authors:  P R Koninckx; M Craessaerts; D Timmerman; F Cornillie; S Kennedy
Journal:  Hum Reprod       Date:  2008-06-12       Impact factor: 6.918

Review 6.  Potential involvement of the immune system in the development of endometriosis.

Authors:  Cleophas M Kyama; Sophie Debrock; Jason M Mwenda; Thomas M D'Hooghe
Journal:  Reprod Biol Endocrinol       Date:  2003-12-02       Impact factor: 5.211
  6 in total

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