Literature DB >> 12450138

Apoptosis induction by wheat-flour sphingoid bases in DLD-1 human colon cancer cells.

Tatsuya Sugawara1, Mikio Kinoshita, Masao Ohnishi, Teruo Miyazawa.   

Abstract

The apoptotic effects of plant sphingoid bases prepared from wheat-flour cerebroside on human colorectal cancer DLD-1 cells were examined. The viability of DLD-1 cells treated with such plant sphingoid bases was reduced in a dose-dependent manner and was similar to that of cells treated with sphingosine. Morphological changes such as condensed chromatin fragments were found, so those sphingoid bases reduced cell viability through causing apoptosis in these cells.

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Year:  2002        PMID： 12450138     DOI： 10.1271/bbb.66.2228

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  4 in total

1.  Structure of Sphingolipids From Sea Cucumber Cucumaria frondosa and Structure-Specific Cytotoxicity Against Human HepG2 Cells.

Authors:  Zicai Jia; Yu Song; Suyuan Tao; Peixu Cong; Xiaoxu Wang; Changhu Xue; Jie Xu
Journal:  Lipids       Date:  2016-02-10       Impact factor: 1.880

2.  Intestinal absorption of dietary maize glucosylceramide in lymphatic duct cannulated rats.

Authors:  Tatsuya Sugawara; Tsuyoshi Tsuduki; Saeko Yano; Mayumi Hirose; Jingjing Duan; Kazuhiko Aida; Ikuo Ikeda; Takashi Hirata
Journal:  J Lipid Res       Date:  2010-03-08       Impact factor: 5.922

3.  Oral glucosylceramide reduces 2,4-dinitrofluorobenzene induced inflammatory response in mice by reducing TNF-alpha levels and leukocyte infiltration.

Authors:  Jingjing Duan; Tatsuya Sugawara; Shota Sakai; Kazuhiko Aida; Takashi Hirata
Journal:  Lipids       Date:  2011-01-11       Impact factor: 1.880

4.  Glucosylceramide Changes Bacterial Metabolism and Increases Gram-Positive Bacteria through Tolerance to Secondary Bile Acids In Vitro.

Authors:  Huanghuang Dai; Akira Otsuka; Kurumi Tanabe; Teruyoshi Yanagita; Jiro Nakayama; Hiroshi Kitagaki
Journal:  Int J Mol Sci       Date:  2022-05-10       Impact factor: 6.208
  4 in total

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