Literature DB >> 12447916

Synthesis and biological evaluation of cytotoxic 6(7)-alkyl-2-hydroxy-1, 4-naphthoquinones.

José M Miguel del Corral1, Maria Angeles Castro, Marina Gordaliza, Maria Luz Martin, Alaide B Oliveira, Simone A Gualberto, Maria Dolores García-Grávalos, Arturo San Feliciano.   

Abstract

Various Diels Alder cycloaddition conditions have been used to optimise the preparation of cytotoxic 6-alkyl-1, 4-naphthoquinones, which were subsequently transformed into 6(7)-alkyl-2-hydroxy-1, 4-naphthoquinones. The compounds thus prepared were evaluated for their cytotoxic activity against several neoplastic cultured cell lines and some of them showed IC50 values below the microM level.

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Year:  2002        PMID： 12447916     DOI： 10.1002/1521-4184(200212)335:9<427::AID-ARDP427>3.0.CO;2-M

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  3 in total

1.  Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.

Authors:  Lynnie Trzoss; Takashi Fukuda; Letícia V Costa-Lotufo; Paula Jimenez; James J La Clair; William Fenical
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-30       Impact factor: 11.205

2.  Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits.

Authors:  Tatiane Freitas Borgati; Maria Fernanda Alves do Nascimento; Juma Fortunato Bernardino; Lunamaura Claudia Oliveira Martins; Alex Gutterres Taranto; Alaíde Braga de Oliveira
Journal:  J Trop Med       Date:  2017-10-31

Review 3.  Bioactive Prenyl- and Terpenyl-Quinones/Hydroquinones of Marine Origin †.

Authors:  Pablo A García; Ángela P Hernández; Arturo San Feliciano; Mª Ángeles Castro
Journal:  Mar Drugs       Date:  2018-08-21       Impact factor: 5.118
  3 in total

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