OBJECTIVES: To identify baseline patient and treatment characteristics that can predict wheelchair dependency within 2 yr. DESIGN: This prospective cohort study included 44 subjects who met study inclusion criteria. The same investigator examined them at 6-mo intervals. Ambulatory status, anthropometric data, muscle strength, range of motion of weight bearing joints, scoliosis, WeeFIM instrument, Functional Status II revised, and use of standing and walking aids. Cox proportional hazards regression analysis and the stepwise technique were used to search for prognostic factors of wheelchair dependency within 2 yr. RESULTS: Children with impaired hip extension and ankle dorsiflexion strength are 11.5 (95% confidence interval, 3.2-40.5) and 3.7 (95% confidence interval, 1.4-9.7) times, respectively, more likely to stop ambulating within 2 yr. CONCLUSIONS: This study confirms that strength loss, specifically in hip extension and ankle dorsiflexion, are the primary predictors of loss of ambulation in Duchenne muscular dystrophy. Further research is needed for medical interventions that can improve hip extension or ankle dorsiflexion and actually can improve ambulation.
OBJECTIVES: To identify baseline patient and treatment characteristics that can predict wheelchair dependency within 2 yr. DESIGN: This prospective cohort study included 44 subjects who met study inclusion criteria. The same investigator examined them at 6-mo intervals. Ambulatory status, anthropometric data, muscle strength, range of motion of weight bearing joints, scoliosis, WeeFIM instrument, Functional Status II revised, and use of standing and walking aids. Cox proportional hazards regression analysis and the stepwise technique were used to search for prognostic factors of wheelchair dependency within 2 yr. RESULTS:Children with impaired hip extension and ankle dorsiflexion strength are 11.5 (95% confidence interval, 3.2-40.5) and 3.7 (95% confidence interval, 1.4-9.7) times, respectively, more likely to stop ambulating within 2 yr. CONCLUSIONS: This study confirms that strength loss, specifically in hip extension and ankle dorsiflexion, are the primary predictors of loss of ambulation in Duchenne muscular dystrophy. Further research is needed for medical interventions that can improve hip extension or ankle dorsiflexion and actually can improve ambulation.
Authors: Sunita Mathur; Donovan J Lott; Claudia Senesac; Sean A Germain; Ravneet S Vohra; H Lee Sweeney; Glenn A Walter; Krista Vandenborne Journal: Arch Phys Med Rehabil Date: 2010-07 Impact factor: 3.966
Authors: Donovan J Lott; Sean C Forbes; Sunita Mathur; Sean A Germain; Claudia R Senesac; H Lee Sweeney; Glenn A Walter; Krista Vandenborne Journal: Neuromuscul Disord Date: 2014-04-13 Impact factor: 4.296
Authors: Il-Young Jung; Jong Hee Chae; Sue Kyung Park; Je Ho Kim; Jung Yoon Kim; Sang Joon Kim; Moon Suk Bang Journal: Ann Rehabil Med Date: 2012-02-29
Authors: K J Hughes; A Rodriguez; K M Flatt; S Ray; A Schuler; B Rodemoyer; V Veerappan; K Cuciarone; A Kullman; C Lim; N Gutta; S Vemuri; V Andriulis; D Niswonger; L Barickman; W Stein; A Singhvi; N E Schroeder; A G Vidal-Gadea Journal: Proc Natl Acad Sci U S A Date: 2019-02-12 Impact factor: 11.205
Authors: Chiara S M Straathof; W C G Truus Overweg-Plandsoen; Gert Jan van den Burg; Anneke J van der Kooi; Jan J G M Verschuuren; Imelda J M de Groot Journal: J Neurol Date: 2009-03-22 Impact factor: 4.849