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Literature DB >> 12446566

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.

Kristina Schoonjans¹, Jean-Sebastien Annicotte, Thierry Huby, Oronza A Botrugno, Elisabeth Fayard, Yukihiko Ueda, John Chapman, Johan Auwerx.

Abstract

The scavenger receptor class B type I (SR-BI), which mediates selective cellular cholesterol uptake from high-density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH-1) and SR-BI are co-expressed in liver and ovary, suggesting that LRH-1 might control the expression of SR-BI in these tissues. LRH-1 induces human and mouse SR-BI promoter activity by binding to an LRH-1 response element in the promoter. Retroviral expression of LRH-1 robustly induces SR-BI, an effect associated with histone H3 acetylation on the SR-BI promoter. The decrease in SR-BI mRNA levels in livers of LRH-1(+/-) animals provides in vivo evidence that LRH-1 regulates SR-BI expression. Our data demonstrate that SR-BI is an LRH-1 target gene and underscore the pivotal role of LRH-1 in reverse cholesterol transport.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12446566 PMCID： PMC1308324 DOI： 10.1093/embo-reports/kvf238

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

24 in total

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Journal: J Biol Chem Date: 2000-06-09 Impact factor: 5.157

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Authors: M Krieger
Journal: Annu Rev Biochem Date: 1999 Impact factor: 23.643

3. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology.

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Journal: Proc Natl Acad Sci U S A Date: 1999-08-03 Impact factor: 11.205

4. Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism.

Authors: A del Castillo-Olivares; G Gil
Journal: Nucleic Acids Res Date: 2001-10-01 Impact factor: 16.971

5. The mouse fetoprotein transcription factor (FTF) gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs, and FTF in turn activates the Hnf3beta, Hnf4alpha, and Hnf1alpha gene promoters.

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Journal: J Biol Chem Date: 2001-01-05 Impact factor: 5.157

6. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.

Authors: J J Repa; S D Turley; J A Lobaccaro; J Medina; L Li; K Lustig; B Shan; R A Heyman; J M Dietschy; D J Mangelsdorf
Journal: Science Date: 2000-09-01 Impact factor: 47.728

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Authors: Y Luo; C P Liang; A R Tall
Journal: J Biol Chem Date: 2001-04-30 Impact factor: 5.157

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Authors: B Goodwin; S A Jones; R R Price; M A Watson; D D McKee; L B Moore; C Galardi; J G Wilson; M C Lewis; M E Roth; P R Maloney; T M Willson; S A Kliewer
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10. Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse.

Authors: K F Kozarsky; M H Donahee; J M Glick; M Krieger; D J Rader
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48 in total

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Authors: Pablo J Fernandez-Marcos; Johan Auwerx; Kristina Schoonjans
Journal: Biochim Biophys Acta Date: 2010-12-29

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Authors: Nicolas Venteclef; Jason C Smith; Bryan Goodwin; Philippe Delerive
Journal: Mol Cell Biol Date: 2006-09 Impact factor: 4.272

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Journal: Proc Natl Acad Sci U S A Date: 2007-08-01 Impact factor: 11.205

6. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development.

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Journal: Mol Cell Biol Date: 2005-05 Impact factor: 4.272