Literature DB >> 12446149

Intracellular mRNA localization: motors move messages.

Hildegard Tekotte1, Ilan Davis.   

Abstract

Intracellular mRNA localization is a common mechanism of post-transcriptional regulation of gene expression. In a wide range of organisms, mRNA localization coupled with translational regulation target the proteins to their site of function. Here, we describe recent exciting evidence that some mRNAs are transported as particles along the cytoskeleton by the molecular motors dynein, kinesin or myosin. We discuss the key questions of how localized mRNAs might be linked to motors and what determines their cytoplasmic destinations.

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Year:  2002        PMID： 12446149     DOI： 10.1016/s0168-9525(02)02819-6

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  47 in total

1.  Visualizing the distribution and transport of mRNAs in living cells.

Authors:  Diana P Bratu; Byeong-Jik Cha; Musa M Mhlanga; Fred Russell Kramer; Sanjay Tyagi
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-28       Impact factor: 11.205

2.  Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability.

Authors:  Jacob Nielsen; Mette Ahm Kristensen; Martin Willemoës; Finn Cilius Nielsen; Jan Christiansen
Journal:  Nucleic Acids Res       Date:  2004-08-16       Impact factor: 16.971

3.  Dual FRET molecular beacons for mRNA detection in living cells.

Authors:  Philip J Santangelo; Brent Nix; Andrew Tsourkas; Gang Bao
Journal:  Nucleic Acids Res       Date:  2004-04-14       Impact factor: 16.971

4.  RNA in centrosomes: structure and possible functions.

Authors:  Konstantin Chichinadze; Ann Lazarashvili; Jaba Tkemaladze
Journal:  Protoplasma       Date:  2012-06-10       Impact factor: 3.356

5.  A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin.

Authors:  Kathryn L Pepple; Aimée E Anderson; Benjamin J Frankfort; Graeme Mardon
Journal:  Genetics       Date:  2006-11-16       Impact factor: 4.562

Review 6.  Cytoskeletal motors in Arabidopsis. Sixty-one kinesins and seventeen myosins.

Authors:  Yuh-Ru Julie Lee; Bo Liu
Journal:  Plant Physiol       Date:  2004-12       Impact factor: 8.340

7.  Nuclear localization signal peptides induce molecular delivery along microtubules.

Authors:  Hanna Salman; Asmahan Abu-Arish; Shachar Oliel; Avraham Loyter; Joseph Klafter; Rony Granek; Michael Elbaum
Journal:  Biophys J       Date:  2005-07-22       Impact factor: 4.033

8.  mRNA localization to the mitochondrial surface allows the efficient translocation inside the organelle of a nuclear recoded ATP6 protein.

Authors:  Valérie Kaltimbacher; Crystel Bonnet; Gaëlle Lecoeuvre; Valérie Forster; José-Alain Sahel; Marisol Corral-Debrinski
Journal:  RNA       Date:  2006-06-02       Impact factor: 4.942

9.  The role of the 3' untranslated region in mRNA sorting to the vicinity of mitochondria is conserved from yeast to human cells.

Authors:  J Sylvestre; A Margeot; C Jacq; G Dujardin; M Corral-Debrinski
Journal:  Mol Biol Cell       Date:  2003-06-13       Impact factor: 4.138

10.  Cholesterol level regulates endosome motility via Rab proteins.

Authors:  Hongtao Chen; Jun Yang; Philip S Low; Ji-Xin Cheng
Journal:  Biophys J       Date:  2007-11-02       Impact factor: 4.033
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