Literature DB >> 12446008

Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis.

M Laurà1, N A Gregson, Y Curmi, R A C Hughes.   

Abstract

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome (GBS). Treatment with LIF at the onset of the disease showed a slight, but not significant, improvement in the clinical course but no effect on nerve histology.

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Year:  2002        PMID: 12446008     DOI: 10.1016/s0165-5728(02)00359-4

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN: 0165-5728            Impact factor:   3.478


  2 in total

1.  The strategies used for treatment of experimental autoimmune neuritis (EAN): a beneficial effect of glatiramer acetate administered intraperitoneally.

Authors:  Ramona Aronovich; Aviva Katzav; Joab Chapman
Journal:  Clin Rev Allergy Immunol       Date:  2012-04       Impact factor: 8.667

2.  CNS-targeted LIF expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis.

Authors:  Helena Slaets; Jerome J A Hendriks; Chris Van den Haute; Frea Coun; Veerle Baekelandt; Piet Stinissen; Niels Hellings
Journal:  Mol Ther       Date:  2010-01-12       Impact factor: 11.454

  2 in total

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