| Literature DB >> 1244383 |
Abstract
The water-soluble proteins of the cerebral gray matter and some enzyme systems (cholinesterase, acetylcholinesterase, lactate dehydrogenase, malate dehydrogenase, acid phosphatase) were studied in 9 autopsy cases of Alzheimer's presenile or senile dementia, 1 case of Pick's disease and 1 case of cerebral arteriosclerosis. The proteins and enzyme patterns were visualized on polyacrylamide gradient gels after electrophoresis. In all patients studied, the profiles of cerebral gray-matter proteins were normal. In the patients with advanced dementia, the enzyme patterns usually were abnormal. Particularly in Alzheimer's disease, the activity of malate dehydrogenase was markedly increased.Entities:
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Year: 1976 PMID： 1244383 DOI： 10.1111/j.1532-5415.1976.tb03247.x
Source DB: PubMed Journal: J Am Geriatr Soc ISSN： 0002-8614 Impact factor: 5.562