Literature DB >> 12443776

Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: key intermediates for H3 histamine receptor ligands.

Miguel F Braña1, Cristina Guisado, Luis Fernando Alguacil, Elisa Garrido, Carmen Pérez-García, Mariano Ruiz-Gayo.   

Abstract

A new synthetic methodology to provide cis-2-(1H-imidazol-4-yl)-cyclopropane carboxylic acids is described. These cyclopropanes are useful for the preparation of novel H(3) receptor agents.

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Year:  2002        PMID： 12443776     DOI： 10.1016/s0960-894x(02)00793-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  1 in total

1.  (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues.

Authors:  Armin de Meijere; Sergei I Kozhushkov; Dmitrii S Yufit; Christian Grosse; Marcel Kaiser; Vitaly A Raev
Journal:  Beilstein J Org Chem       Date:  2014-12-03       Impact factor: 2.883
  1 in total

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