Literature DB >> 12443775

Synthesis and biological evaluation of aristolactams.

Axel Couture1, Eric Deniau, Pierre Grandclaudon, Hélène Rybalko-Rosen, Stéphane Léonce, Bruno Pfeiffer, Pierre Renard.   

Abstract

A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line.

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Year:  2002        PMID： 12443775     DOI： 10.1016/s0960-894x(02)00794-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation.

Authors:  Li Li; Xu Wang; Jing Chen; Hong Ding; Yu Zhang; Tian-Cen Hu; Li-Hong Hu; Hua-Liang Jiang; Xu Shen
Journal:  Acta Pharmacol Sin       Date:  2009-10       Impact factor: 6.150

2.  Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription.

Authors:  YoungHyun Shin; Chul Min Park; Hong Gi Kim; Dong-Eun Kim; Min Suk Choi; Jeong-Ah Kim; Byeong-Sun Choi; Cheol-Hee Yoon
Journal:  Virol Sin       Date:  2020-08-10       Impact factor: 4.327

3.  Synthesis of 3-Alkylideneisoindolin-1-ones via Sonogashira Cyclocarbonylative Reactions of 2-Ethynylbenzamides.

Authors:  Gianluigi Albano; Stefano Giuntini; Laura Antonella Aronica
Journal:  J Org Chem       Date:  2020-07-14       Impact factor: 4.354

4.  Predicting the possibility of two newly isolated phenetheren ring containing compounds from Aristolochia manshuriensis as CDK2 inhibitors.

Authors:  Ali Abdullah Alshatwi; Tarique Noorul Hasan; Naveed Ahmed Syed; Gowhar Shafi
Journal:  Bioinformation       Date:  2011-12-10

Review 5.  The chemistry of isoindole natural products.

Authors:  Klaus Speck; Thomas Magauer
Journal:  Beilstein J Org Chem       Date:  2013-10-10       Impact factor: 2.883

6.  Rapid and Simultaneous Quantification of Six Aristolochic Acids and Two Lignans in Asari Radix et Rhizoma Using Ultra-Performance Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry.

Authors:  Hanze Liu; Xuemei Cheng; Huida Guan; Changhong Wang
Journal:  J Anal Methods Chem       Date:  2022-09-10       Impact factor: 2.594

7.  DNA adducts of aristolochic acid II: total synthesis and site-specific mutagenesis studies in mammalian cells.

Authors:  Sivaprasad Attaluri; Radha R Bonala; In-Young Yang; Mark A Lukin; Yujing Wen; Arthur P Grollman; Masaaki Moriya; Charles R Iden; Francis Johnson
Journal:  Nucleic Acids Res       Date:  2009-10-23       Impact factor: 16.971

Review 8.  Peppers: A "Hot" Natural Source for Antitumor Compounds.

Authors:  Micael Rodrigues Cunha; Maurício Temotheo Tavares; Thais Batista Fernandes; Roberto Parise-Filho
Journal:  Molecules       Date:  2021-03-10       Impact factor: 4.411
  8 in total

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