Literature DB >> 12443769

Synthesis of new Targretin analogues that induce apoptosis in leukemia HL-60 cells.

Jean-Yves Winum1, Stephen Baghdiguian, Thérèse Commes, Alain Leydet, Jean-Louis Montero.   

Abstract

Four new analogues of Targretin where the carboxylic acid function was replaced by an N,N-dimethyl-S-aryl carbamate or N,N-dimethyl-O-arylthiocarbamate function, were synthesized. Compounds 5, 6 and 7 have shown to be more potent than the parent compound to induce apoptosis of HL-60 cells.

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Year:  2002        PMID： 12443769     DOI： 10.1016/s0960-894x(02)00803-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Modeling, synthesis and biological evaluation of potential retinoid X receptor-selective agonists: novel halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).

Authors:  Julie K Furmick; Ichiro Kaneko; Angela N Walsh; Joanna Yang; Jaskaran S Bhogal; Geoffrey M Gray; Juan C Baso; Drew O Browder; Jessica L S Prentice; Luis A Montano; Chanh C Huynh; Lisa M Marcus; Dorian G Tsosie; Jungeun S Kwon; Alexis Quezada; Nicole M Reyes; Brittney Lemming; Puneet Saini; Arjan van der Vaart; Thomas L Groy; Pamela A Marshall; Peter W Jurutka; Carl E Wagner
Journal:  ChemMedChem       Date:  2012-09       Impact factor: 3.466

2.  Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).

Authors:  Carl E Wagner; Peter W Jurutka; Pamela A Marshall; Thomas L Groy; Arjan van der Vaart; Joseph W Ziller; Julie K Furmick; Mark E Graeber; Erik Matro; Belinda V Miguel; Ivy T Tran; Jungeun Kwon; Jamie N Tedeschi; Shahram Moosavi; Amina Danishyar; Joshua S Philp; Reina O Khamees; Jevon N Jackson; Darci K Grupe; Syed L Badshah; Justin W Hart
Journal:  J Med Chem       Date:  2009-10-08       Impact factor: 7.446
  2 in total

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