Literature DB >> 12443092

Shortcut to mycothiol analogues.

Spencer Knapp1, Silvia Gonzalez, David S Myers, Lisa L Eckman, Carole A Bewley.   

Abstract

[structure: see text] The synthesis of a simplified thioglycosidic analogue (2) of mycothiol (1) is described. Evaluation of 2 against mycothiol S-conjugate amidase from Mycobacterium tuberculosis reveals good specific activity (7500 nmol min(-)(1) mg-protein(-)(1), vs 14 200 for 1), indicating that 2 can serve as a starting point for antitubercular drug design.

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Year:  2002        PMID： 12443092     DOI： 10.1021/ol0269796

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Intramolecular alpha-glucosaminidation: synthesis of mycothiol.

Authors:  Kehinde Ajayi; Vinay V Thakur; Robert C Lapo; Spencer Knapp
Journal:  Org Lett       Date:  2010-06-04       Impact factor: 6.005

Review 2.  New targets and inhibitors of mycobacterial sulfur metabolism.

Authors:  Hanumantharao Paritala; Kate S Carroll
Journal:  Infect Disord Drug Targets       Date:  2013-04

Review 3.  Drug targets in mycobacterial sulfur metabolism.

Authors:  Devayani P Bhave; Wilson B Muse; Kate S Carroll
Journal:  Infect Disord Drug Targets       Date:  2007-06

Review 4.  Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.

Authors:  Gerald L Newton; Nancy Buchmeier; Robert C Fahey
Journal:  Microbiol Mol Biol Rev       Date:  2008-09       Impact factor: 11.056

5.  rac-2,2'-(Thiane-2,6-di-yl)bis-[1-(4-bromo-phen-yl)ethanone].

Authors:  Li-Qiang Liu; Jing-Kui Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-04-07
  5 in total

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