Rift valley fever.

Rift Valley fever virus is an arthropod-borne Phlebovirus endemic in sub-Saharan Africa. Outbreaks also have occurred in Egypt, Madagascar, and most recently in the Arabian peninsula. Large epizootics occur at irregular intervals in seasons of above-average rainfall with persistent flooding and the appearance of large numbers of floodwater-breeding Aedine mosquitoes. The virus is transmitted transovarially and can remain dormant in mosquito eggs during dry interepizootic periods. Low-level virus circulation occurs in high-rainfall forested areas, although individual cases of the disease rarely are recognized. RVF is characterized by abortion in pregnant animals and a high mortality in newborn lambs, kids, and calves. Susceptibility to disease is related to age and breed, with severe disease occurring in the young of exotic sheep and cattle breeds. RVF is a zoonosis, and human beings experience an influenza-like illness and, more rarely, complications such as encephalitis or retinitis. The virus causes a severe hepatitis, particularly in aborted fetuses and newborn lambs. The disease must be differentiated from other conditions that cause death with hepatitis and jaundice. Both an inactivated and a live attenuated vaccine are available. New-generation vaccines are being tested, because the existing mousebrain-attenuated strain induces fetal teratology or abortion in a percentage of pregnant animals. Diagnosis is based on histopathology or the demonstration of viral antigen or antibody.