BACKGROUND: Before 2001, echovirus 13 accounted for only 65 of approximately 45,000 reported enteroviral isolates in the United States. During spring 2001, several outbreaks of echovirus 13 meningitis occurred, primarily affecting children. We investigated a large outbreak in Shelby County, TN, to determine the characteristics and clinical manifestations of echovirus 13 meningitis. METHODS: We identified cases of aseptic meningitis at a children's hospital from April through August 2001 by reviewing discharge records. For patients with laboratory-confirmed echovirus 13 meningitis, we reviewed charts and interviewed parents. RESULTS: We identified 303 hospitalizations caused by aseptic meningitis at the children's hospital from April through August. Hospitalizations peaked in May. Twenty-six percent of hospitalized patients were infants age <4 months; 63% were male. Hospitalization rates were 3 times greater among black children than among white children (140 vs. 47 per 100,000). Echovirus 13 was isolated from specimens from 37 (80%) of 46 patients with positive viral cultures. Of those with laboratory-confirmed echovirus 13, 35 (95%) had fever, 26 (70%) had vomiting, 20 (54%) had headache, 16 (43%) had stiff neck and 16 (43%) had irritability. No sequelae or deaths were identified. CONCLUSIONS: Echovirus 13 emerged as a predominant strain of enterovirus associated with aseptic meningitis in the United States in 2001. In this outbreak echovirus 13 meningitis appeared to be clinically indistinguishable from aseptic meningitis caused by other enteroviruses.
BACKGROUND: Before 2001, echovirus 13 accounted for only 65 of approximately 45,000 reported enteroviral isolates in the United States. During spring 2001, several outbreaks of echovirus 13meningitis occurred, primarily affecting children. We investigated a large outbreak in Shelby County, TN, to determine the characteristics and clinical manifestations of echovirus 13meningitis. METHODS: We identified cases of aseptic meningitis at a children's hospital from April through August 2001 by reviewing discharge records. For patients with laboratory-confirmed echovirus 13meningitis, we reviewed charts and interviewed parents. RESULTS: We identified 303 hospitalizations caused by aseptic meningitis at the children's hospital from April through August. Hospitalizations peaked in May. Twenty-six percent of hospitalized patients were infants age <4 months; 63% were male. Hospitalization rates were 3 times greater among black children than among white children (140 vs. 47 per 100,000). Echovirus 13 was isolated from specimens from 37 (80%) of 46 patients with positive viral cultures. Of those with laboratory-confirmed echovirus 13, 35 (95%) had fever, 26 (70%) had vomiting, 20 (54%) had headache, 16 (43%) had stiff neck and 16 (43%) had irritability. No sequelae or deaths were identified. CONCLUSIONS:Echovirus 13 emerged as a predominant strain of enterovirus associated with aseptic meningitis in the United States in 2001. In this outbreak echovirus 13meningitis appeared to be clinically indistinguishable from aseptic meningitis caused by other enteroviruses.
Authors: Inge Thoelen; Elien Moës; Philippe Lemey; Sara Mostmans; Elke Wollants; A Michael Lindberg; Anne-Mieke Vandamme; Marc Van Ranst Journal: J Clin Microbiol Date: 2004-03 Impact factor: 5.948
Authors: Armando M De Palma; Ward Heggermont; Kjerstin Lanke; Bruno Coutard; Mirko Bergmann; Anna-Maria Monforte; Bruno Canard; Erik De Clercq; Alba Chimirri; Gerhard Pürstinger; Jacques Rohayem; Frank van Kuppeveld; Johan Neyts Journal: J Virol Date: 2008-03-12 Impact factor: 5.103
Authors: Bonita E Lee; Rupesh Chawla; Joanne M Langley; Sarah E Forgie; Mohammed Al-Hosni; Krista Baerg; Entesar Husain; James Strong; Joan L Robinson; Upton Allen; Barbara J Law; Simon Dobson; H Dele Davies Journal: BMC Infect Dis Date: 2006-04-10 Impact factor: 3.090