Literature DB >> 12441189

Synthesis of (25R)-26-hydroxycholesterol.

John R Williams1, Deping Chai, Dominic Wright.   

Abstract

We describe the synthesis of (25R)-cholest-5-en-3beta,26-diol ((25R)-26-hydroxycholesterol) from diosgenin in four steps in 58% overall, yield via a modified Clemmensen reduction followed by a Barton deoxygenation reaction.

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Year:  2002        PMID： 12441189     DOI： 10.1016/s0039-128x(02)00060-0

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  6 in total

Review 1.  Isolation and synthesis of shark-repelling saponins.

Authors:  John R Williams; Hua Gong
Journal:  Lipids       Date:  2004-08       Impact factor: 1.880

2.  Synthesis of side-chain oxysterols and their enantiomers through cross-metathesis reactions of Δ22 steroids.

Authors:  David P Brownholland; Douglas F Covey
Journal:  Steroids       Date:  2017-03-12       Impact factor: 2.668

3.  Studies toward the synthesis of the shark repellent pavoninin-5.

Authors:  John R Williams; Deping Chai; Hua Gong; Wei Zhao; Dominic Wright
Journal:  Lipids       Date:  2002-12       Impact factor: 1.880

4.  Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1.

Authors:  Kamila Z Rosłoniec; Maarten H Wilbrink; Jenna K Capyk; William W Mohn; Martin Ostendorf; Robert van der Geize; Lubbert Dijkhuizen; Lindsay D Eltis
Journal:  Mol Microbiol       Date:  2009-10-15       Impact factor: 3.501

Review 5.  Biological activities and syntheses of steroidal saponins: the shark-repelling pavoninins.

Authors:  John R Williams; Hua Gong
Journal:  Lipids       Date:  2006-12-19       Impact factor: 1.880

Review 6.  New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis.

Authors:  Yanting Che; Jingzhi Yang; Fen Tang; Ziheng Wei; Yufan Chao; Na Li; Henghui Li; Si Wu; Xin Dong
Journal:  Int J Mol Sci       Date:  2022-02-11       Impact factor: 5.923
  6 in total

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