Literature DB >> 12440877

Acid-promoted DNA-cleaving activities and total synthesis of varacin C.

Alex H F Lee1, Jian Chen, Dongsheng Liu, Thomas Y C Leung, Albert S C Chan, Tianhu Li.   

Abstract

The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.

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Year:  2002        PMID： 12440877     DOI： 10.1021/ja020531i

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  8 in total

1.  C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy.

Authors:  Wang-Yong Yang; Boris Breiner; Serguei V Kovalenko; Chi Ben; Mani Singh; Shauna N LeGrand; Qing-Xiang Amy Sang; Geoffrey F Strouse; John A Copland; Igor V Alabugin
Journal:  J Am Chem Soc       Date:  2009-08-19       Impact factor: 15.419

2.  A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice.

Authors:  Alexander V Kulikov; Maria A Tikhonova; Elizabeth A Kulikova; Konstantin P Volcho; Tatyana M Khomenko; Nariman F Salakhutdinov; Nina K Popova
Journal:  Psychopharmacology (Berl)       Date:  2011-11-30       Impact factor: 4.530

3.  Synthesis, characterization, mechanism of decomposition, and antiproliferative activity of a class of PEGylated benzopolysulfanes structurally similar to the natural product varacin.

Authors:  Adaickapillai Mahendran; Angela Vuong; David Aebisher; Yaqiong Gong; Robert Bittman; Gilbert Arthur; Akira Kawamura; Alexander Greer
Journal:  J Org Chem       Date:  2010-08-20       Impact factor: 4.354

4.  Synthesis and antiproliferative properties of a new ceramide analog of varacin.

Authors:  Adaickapillai Mahendran; Ashwini A Ghogare; Robert Bittman; Gilbert Arthur; Alexander Greer
Journal:  Chem Phys Lipids       Date:  2015-08-05       Impact factor: 3.329

5.  Varacin-1, a novel analog of varacin C, induces p53-independent apoptosis in cancer cells through ROS-mediated reduction of XIAP.

Authors:  Jing Zhou; Wen-Li Li; Zi-Xuan Wang; Nai-Yuan Chen; Yue Tang; Xiao-Xiao Hu; Jing-Huan Deng; Yixin Lu; Guo-Dong Lu
Journal:  Acta Pharmacol Sin       Date:  2018-05-17       Impact factor: 6.150

6.  The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product.

Authors:  Santhosh Sivaramakrishnan; Leonid Breydo; Daekyu Sun; Kent S Gates
Journal:  Bioorg Med Chem Lett       Date:  2012-04-12       Impact factor: 2.823

7.  Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).

Authors:  Lester J Lambert; Stefan Grotegut; Maria Celeridad; Palak Gosalia; Laurent Js De Backer; Andrey A Bobkov; Sumeet Salaniwal; Thomas Dy Chung; Fu-Yue Zeng; Ian Pass; Paul J Lombroso; Nicholas Dp Cosford; Lutz Tautz
Journal:  Int J Mol Sci       Date:  2021-04-23       Impact factor: 5.923

8.  Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells.

Authors:  Steven Behnisch-Cornwell; Siva Sankar Murthy Bandaru; Martin Napierkowski; Lisa Wolff; Muhammad Zubair; Claudia Urbainsky; Christopher Lillig; Carola Schulzke; Patrick J Bednarski
Journal:  ChemMedChem       Date:  2020-05-06       Impact factor: 3.466
  8 in total

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