R A Rinsky1, R W Hornung, S R Silver, C Y Tseng. 1. Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA.
Abstract
BACKGROUND: Previous studies of a cohort of rubber hydrochloride workers indicated an association between benzene exposure and excess mortality from leukemia and multiple myeloma. To determine whether risks remain elevated with increasing time since plant shutdown, we extended follow-up from 1981 through 1996. MATERIALS AND METHODS: We evaluated risk using standardized mortality ratios (SMR) and generalized Cox proportional hazards regression models. RESULTS: Five new leukemia cases were observed in benzene-exposed white males, but the summary SMR for this group declined from 3.37 (95% CI = 1.54-6.41) to 2.56 (95% CI = 1.43-4.22). In regression models, cumulative exposure was significantly associated with elevated relative risks for leukemia mortality. Four new multiple myeloma deaths occurred, three of which were in workers judged to be unexposed. CONCLUSIONS: These findings reaffirm the leukemogenic effects of benzene exposure and suggest that excess risk diminishes with time.
BACKGROUND: Previous studies of a cohort of rubber hydrochloride workers indicated an association between benzene exposure and excess mortality from leukemia and multiple myeloma. To determine whether risks remain elevated with increasing time since plant shutdown, we extended follow-up from 1981 through 1996. MATERIALS AND METHODS: We evaluated risk using standardized mortality ratios (SMR) and generalized Cox proportional hazards regression models. RESULTS: Five new leukemia cases were observed in benzene-exposed white males, but the summary SMR for this group declined from 3.37 (95% CI = 1.54-6.41) to 2.56 (95% CI = 1.43-4.22). In regression models, cumulative exposure was significantly associated with elevated relative risks for leukemia mortality. Four new multiple myeloma deaths occurred, three of which were in workers judged to be unexposed. CONCLUSIONS: These findings reaffirm the leukemogenic effects of benzene exposure and suggest that excess risk diminishes with time.
Authors: Lorenz R Rhomberg; Lisa A Bailey; Julie E Goodman; Ali K Hamade; David Mayfield Journal: Crit Rev Toxicol Date: 2011-06-02 Impact factor: 5.635
Authors: Jelle Vlaanderen; Lützen Portengen; Stephen M Rappaport; Deborah C Glass; Hans Kromhout; Roel Vermeulen Journal: Am J Epidemiol Date: 2011-07-10 Impact factor: 4.897
Authors: Gabriella Andreotti; Stella Koutros; Jonathan N Hofmann; Dale P Sandler; Jay H Lubin; Charles F Lynch; Catherine C Lerro; Anneclaire J De Roos; Christine G Parks; Michael C Alavanja; Debra T Silverman; Laura E Beane Freeman Journal: J Natl Cancer Inst Date: 2018-05-01 Impact factor: 13.506
Authors: Catherine Bulka; Loretta J Nastoupil; Jean L Koff; Leon Bernal-Mizrachi; Kevin C Ward; Jessica N Williams; A Rana Bayakly; Jeffrey M Switchenko; Lance A Waller; Christopher R Flowers Journal: South Med J Date: 2016-10 Impact factor: 0.954