BACKGROUND: Recent studies show that almost all patients who have rejected a kidney transplant had human leukocyte antigen (HLA) antibodies. In this study, we sought to determine whether patients develop HLA antibodies before chronic rejection. METHODS: For the past 8 years, 139 patients who had undergone kidney transplantation were systematically examined, using an enzyme-linked immunosorbent assay-based method, for the development of class-I and class-II HLA antibodies 3 months, 6 months, and yearly after transplantation. Chronic rejection was diagnosed by biopsy. RESULTS: Among 29 patients with chronic rejection, 100% of the patients had HLA antibodies before rejection. Of these patients, 14 patients developed antibodies de novo. In contrast, among 110 patients with stable function, 27% of the patients developed HLA antibodies posttransplant (P<0.001). CONCLUSIONS: HLA antibodies were found in 29 consecutive cases of chronic rejection failures as much as one year before the loss of grafts. We conclude that HLA antibodies may be a prerequisite for chronic immunologic rejection.
BACKGROUND: Recent studies show that almost all patients who have rejected a kidney transplant had human leukocyte antigen (HLA) antibodies. In this study, we sought to determine whether patients develop HLA antibodies before chronic rejection. METHODS: For the past 8 years, 139 patients who had undergone kidney transplantation were systematically examined, using an enzyme-linked immunosorbent assay-based method, for the development of class-I and class-II HLA antibodies 3 months, 6 months, and yearly after transplantation. Chronic rejection was diagnosed by biopsy. RESULTS: Among 29 patients with chronic rejection, 100% of the patients had HLA antibodies before rejection. Of these patients, 14 patients developed antibodies de novo. In contrast, among 110 patients with stable function, 27% of the patients developed HLA antibodies posttransplant (P<0.001). CONCLUSIONS: HLA antibodies were found in 29 consecutive cases of chronic rejection failures as much as one year before the loss of grafts. We conclude that HLA antibodies may be a prerequisite for chronic immunologic rejection.
Authors: Fabrice Porcheray; Julie DeVito; Beow Y Yeap; Lijuan Xue; Ian Dargon; Rosemary Paine; Timothy C Girouard; Susan L Saidman; Robert B Colvin; Waichi Wong; Emmanuel Zorn Journal: Transplantation Date: 2010-05-27 Impact factor: 4.939
Authors: Markus Wahrmann; Bernd Döhler; Andrea Ruhenstroth; Helmuth Haslacher; Thomas Perkmann; Markus Exner; Andrew J Rees; Georg A Böhmig Journal: J Am Soc Nephrol Date: 2010-12-16 Impact factor: 10.121
Authors: Julio Pascual; Milagros D Samaniego; José R Torrealba; Jon S Odorico; Arjang Djamali; Yolanda T Becker; Barbara Voss; Glen E Leverson; Stuart J Knechtle; Hans W Sollinger; John D Pirsch Journal: J Am Soc Nephrol Date: 2008-01-30 Impact factor: 10.121
Authors: Eduardo Reyes-Vargas; Igor Y Pavlov; Thomas B Martins; Jason J Schwartz; Harry R Hill; Julio C Delgado Journal: J Clin Lab Anal Date: 2009 Impact factor: 2.352