Literature DB >> 12438935

Citicoline has a protective effect on damaged retinal ganglion cells in mouse culture retina.

Toshiyuki Oshitari1, Naoya Fujimoto, Emiko Adachi-Usami.   

Abstract

Some clinical reports indicate that exogenous CDP-choline (citicoline) may have a therapeutic effect in patients with glaucoma. However, the precise effect of citicoline on damaged retinal ganglion cells (RGCs) remains to be explained. We performed tissue culture of mouse retinal explants and investigated the effect of citicoline on damaged RGCs by the quantitative analysis of TdT-dUTP terminal nick-end labeling (TUNEL) staining and the assessment of the number of regenerating neurites. The TUNEL-positive ratio in 0.1-10 micromol/l citicoline-treated retina was very low, and the number of regenerating neurites increased more than in control retina. Our findings suggest that citicoline has a protective effect on damaged RGCs in tissue culture of retina.

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Year:  2002        PMID： 12438935     DOI： 10.1097/00001756-200211150-00023

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  23 in total

1.  Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma.

Authors:  Vincenzo Parisi; Marco Centofanti; Lucia Ziccardi; Lucia Tanga; Manuele Michelessi; Gloria Roberti; Gianluca Manni
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-05-26       Impact factor: 3.117

2.  Effect of oral citicoline therapy on retinal nerve fiber layer and ganglion cell-inner plexiform layer in patients with primary open angle glaucoma.

Authors:  Asena Keles Sahin; Hasan Burhanettin Kapti; Aslihan Uzun
Journal:  Int J Ophthalmol       Date:  2022-03-18       Impact factor: 1.779

Review 3.  Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders.

Authors:  Rao Muralikrishna Adibhatla; J F Hatcher
Journal:  Neurochem Res       Date:  2005-01       Impact factor: 3.996

4.  Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control.

Authors:  Yolandi van der Merwe; Matthew C Murphy; Jeffrey R Sims; Muneeb A Faiq; Xiao-Ling Yang; Leon C Ho; Ian P Conner; Yu Yu; Christopher K Leung; Gadi Wollstein; Joel S Schuman; Kevin C Chan
Journal:  Neurotherapeutics       Date:  2021-04-13       Impact factor: 7.620

Review 5.  Neuroprotective properties of citicoline: facts, doubts and unresolved issues.

Authors:  Pawel Grieb
Journal:  CNS Drugs       Date:  2014-03       Impact factor: 5.749

6.  Combination of Neuroprotective and Regenerative Agents for AGE-Induced Retinal Degeneration: In Vitro Study.

Authors:  Guzel Bikbova; Toshiyuki Oshitari; Takayuki Baba; Shuichi Yamamoto
Journal:  Biomed Res Int       Date:  2017-05-09       Impact factor: 3.411

7.  A preliminary study of the neuroprotective role of citicoline eye drops in glaucomatous optic neuropathy.

Authors:  Gloria Roberti; Lucia Tanga; Vincenzo Parisi; Massimo Sampalmieri; Marco Centofanti; Gianluca Manni
Journal:  Indian J Ophthalmol       Date:  2014-05       Impact factor: 1.848

Review 8.  Citicoline: A Food Beneficial for Patients Suffering from or Threated with Glaucoma.

Authors:  Pawel Grieb; Anselm Jünemann; Marek Rekas; Robert Rejdak
Journal:  Front Aging Neurosci       Date:  2016-04-08       Impact factor: 5.750

Review 9.  Cytidine 5'-Diphosphocholine (Citicoline) in Glaucoma: Rationale of Its Use, Current Evidence and Future Perspectives.

Authors:  Gloria Roberti; Lucia Tanga; Manuele Michelessi; Luciano Quaranta; Vincenzo Parisi; Gianluca Manni; Francesco Oddone
Journal:  Int J Mol Sci       Date:  2015-11-30       Impact factor: 5.923

Review 10.  Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy.

Authors:  Ming-Shuo Sun; Hang Jin; Xin Sun; Shuo Huang; Fu-Liang Zhang; Zhen-Ni Guo; Yi Yang
Journal:  Oxid Med Cell Longev       Date:  2018-01-31       Impact factor: 6.543
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