Literature DB >> 12438104

Effects of methyllycaconitine and related analogues on bovine adrenal alpha3beta4* nicotinic acetylcholine receptors.

Darrell L Bryant1, R Benjamin Free, Sara M Thomasy, David J Lapinsky, K A Ismail, K M Arason, Stephen C Bergmeier, Dennis B McKay.   

Abstract

Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12438104     DOI： 10.1111/j.1749-6632.2002.tb04448.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  3 in total

1.  3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors.

Authors:  Brandon J Henderson; Crina M Orac; Iwona Maciagiewicz; Stephen C Bergmeier; Dennis B McKay
Journal:  Bioorg Med Chem Lett       Date:  2011-11-20       Impact factor: 2.823

2.  An alpha3beta4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons.

Authors:  Kyu-Sang Park; Seung-Kyu Cha; Min-Jeong Kim; Dae-Ran Kim; Seong-Woo Jeong; Joong-Woo Lee; In Deok Kong
Journal:  Pflugers Arch       Date:  2006-05-20       Impact factor: 3.657

3.  Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor.

Authors:  Madeline Nieves-Cintrón; Daniel Caballero-Rivera; Walter I Silva; Manuel F Navedo; José A Lasalde-Dominicci
Journal:  J Neurosci Res       Date:  2008-10       Impact factor: 4.164
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.