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Literature DB >> 1243629

Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol.

Abstract

4-Dimethylaminophenol hydrochloride (DMAP), 20mg/kg i.v., was found to oxidize in rats as much as 50% of the hemoglobin to ferrihemoglobin but did not cause kidney lesions. 4-Aminophenol hydrochloride, 400 mg/kg i.v., oxidized only 25% of the hemoglobin and produced large tubular necroses. In highly toxic doses only, e.g., twice the LD50, DMAP also produced tubular necroses.

Entities: Chemical Disease Species

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Year: 1975 PMID： 1243629 DOI： 10.1007/bf00353854

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

6 in total

1. [Oxidation of aniline to nitrosobenzene in dogs].

Authors: M KIESE
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1959

2. The role of N,N-dimethylaniline-N-oxide in the formation of hemiglobin following the absorption of N,N-dimethylaniline.

Authors: M Kiese; E Rauscher; N Weger
Journal: Naunyn Schmiedebergs Arch Pharmakol Exp Pathol Date: 1966

3. Formation of ferrihaemoglobin with aminophenols in the human for the treatment of cyanide poisoning.

Authors: M Kiese; N Weger
Journal: Eur J Pharmacol Date: 1969-07 Impact factor: 4.432

4. Nephrotoxicity and molecular structure.

Authors: I C Calder; P J Williams; R A Woods; C C Funder; C R Green; K N Ham; J D Tange
Journal: Xenobiotica Date: 1975-05 Impact factor: 1.908

5. Kidney lesions induced in rats by p-aminophenol.

Authors: C R Green; K N Ham; J D Tange
Journal: Br Med J Date: 1969-01-18

6. Comparative nephrotoxicity of aspirin and phenacetin derivatives.

Authors: I C Calder; C C Funder; C R Green; K N Ham; J D Tange
Journal: Br Med J Date: 1971-11-27

6 in total

5 in total

Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol.

1. [Oxidation of aniline to nitrosobenzene in dogs].

2. The role of N,N-dimethylaniline-N-oxide in the formation of hemiglobin following the absorption of N,N-dimethylaniline.

3. Formation of ferrihaemoglobin with aminophenols in the human for the treatment of cyanide poisoning.

4. Nephrotoxicity and molecular structure.

5. Kidney lesions induced in rats by p-aminophenol.

6. Comparative nephrotoxicity of aspirin and phenacetin derivatives.

1. Biotransformation and some effects of 2-dimethylamino-4-(N-methylanilino)-phenol in dogs.

2. Nephrotoxicity of aminophenols: effects of 4-dimethylaminophenol on isolated rat kidney tubules.

3. Acute oral toxicity of 4-dimethylaminophenol to the gastrointestinal tract, liver and kidney of the rat.

4. Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rat.

5. Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors.