Biliary excretion of 64Cu, 65Zn and 203Hg in the rat with liver injury induced by CCl4.

In rats the effect of a chronic administration of CCl4 on the excretion and disstribution of 64Cu, 65Zn, and 203Hg was investigated. The bilary excretion of these metals was studied with particular attention. It was found that total excretion of 64Cu, 65Zn, or 203Hg from the organism did not change significantly in comparison with the control groupp, but the ratio of individual excretion pathways did change. The course of excretion curves regarding the bile in exposed animals is prolonged. The histologic examination of the livers revealed a large interindividual variability in the response of the liver tissue to the same CCl4 exposure. Differences in distribution in the kidneys and livers in exposed and control animals was also found.