Literature DB >> 12436193

Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population.

Susumu Saito1, Aritoshi Iida, Akihiro Sekine, Chie Ogawa, Saori Kawauchi, Shoko Higuchi, Yusuke Nakamura.   

Abstract

We screened DNAs of 48 Japanese individuals for single-nucleotide polymorphisms (SNPs) in six genes encoding proteins of the solute carrier (SLC) family by direct sequencing of their entire genomic regions except for repetitive-sequence elements. This approach identified 213 SNPs and 25 insertion/deletion polymorphisms among the six genes. On average, we identified 1 SNP in every 509 nucleotides. Of the 213 SNPs, 14 were identified in the SLC10A1 gene, 51 in SLC15A1, 29 in SLC22A1, 27 in SLC22A2, 54 in SLC22A4, and 38 in SLC22A5. Eight were located in 5' flanking regions, 172 in introns, 25 in exons, and 8 in 3' flanking regions. These variants should contribute to investigations of possible correlations between genotypes and phenotypes as regards disease susceptibilities or responsiveness to drug therapy.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12436193     DOI： 10.1007/s100380200088

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  19 in total

1.  Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3).

Authors:  Andreas Lazar; Dirk Gründemann; Reinhard Berkels; Dirk Taubert; Tim Zimmermann; Edgar Schömig
Journal:  J Hum Genet       Date:  2003-04-09       Impact factor: 3.172

2.  Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP Maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs.

Authors:  Naoyuki Kamatani; Akihiro Sekine; Takuya Kitamoto; Aritoshi Iida; Susumu Saito; Akifumi Kogame; Eisuke Inoue; Manabu Kawamoto; Masayoshi Harigai; Yusuke Nakamura
Journal:  Am J Hum Genet       Date:  2004-06-16       Impact factor: 11.025

3.  Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus.

Authors:  Aritoshi Iida; Susumu Saito; Akihiro Sekine; Wataru Tabei; Yukie Kataoka; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2004-06-18       Impact factor: 3.172

4.  Inference from the relationships between linkage disequilibrium and allele frequency distributions of 240 candidate SNPs in 109 drug-related genes in four Asian populations.

Authors:  Pei-Chieng Cha; Ryo Yamada; Akihiro Sekine; Yusuke Nakamura; Chong-Lek Koh
Journal:  J Hum Genet       Date:  2004-09-11       Impact factor: 3.172

5.  Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors.

Authors:  Aritoshi Iida; Susumu Saito; Akihiro Sekine; Yukie Kataoka; Wataru Tabei; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2004-03-20       Impact factor: 3.172

6.  Identification of 156 novel SNPs in 29 genes encoding G-protein coupled receptors.

Authors:  Aritoshi Iida; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2005-04-12       Impact factor: 3.172

7.  Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease.

Authors:  Keiko Yamazaki; Masakazu Takazoe; Torao Tanaka; Toshiki Ichimori; Susumu Saito; Aritoshi Iida; Yoshihiro Onouchi; Akira Hata; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2004-10-19       Impact factor: 3.172

8.  Identification of mutations and evaluation of cardiomyopathy in Turkish patients with primary carnitine deficiency.

Authors:  M Kilic; R K Ozgül; T Coşkun; D Yücel; M Karaca; H S Sivri; A Tokatli; M Sahin; T Karagöz; A Dursun
Journal:  JIMD Rep       Date:  2011-09-22

Review 9.  Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.

Authors:  Tiziano Verri; Amilcare Barca; Paola Pisani; Barbara Piccinni; Carlo Storelli; Alessandro Romano
Journal:  J Comp Physiol B       Date:  2016-11-01       Impact factor: 2.200

10.  Association of genetic variation of sodium taurocholate cotransporting polypeptide with chronic hepatitis B virus infection.

Authors:  Na Li; Pingping Zhang; Cuiling Yang; Qianqian Zhu; Zhu Li; Fang Li; Qunying Han; Yawen Wang; Yi Lv; Ping Wei; Zhengwen Liu
Journal:  Genet Test Mol Biomarkers       Date:  2014-04-15
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.