Literature DB >> 12436114

Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization.

Emanuela Izzo1, Rémi Martin-Fardon, George F Koob, Friedbert Weiss, Pietro Paolo Sanna.   

Abstract

Drug addiction has been linked to protracted functional changes in neural circuits involved in motivation that can lead to drug dependence, craving and relapse. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signal transduction pathway in long-lasting behavioral sensitization to cocaine in rats, an animal model of the long-lasting functional changes induced by repeated drug use. Our results show that PI3K is required for the expression, but not the induction, of behavioral sensitization to cocaine.

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Year:  2002        PMID： 12436114     DOI： 10.1038/nn977

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  26 in total

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Authors:  Carlos A Bolaños; Eric J Nestler
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4.  D1 and D2 dopamine receptors differentially mediate the activation of phosphoproteins in the striatum of amphetamine-sensitized rats.

Authors:  Xiangdang Shi; Jacqueline F McGinty
Journal:  Psychopharmacology (Berl)       Date:  2010-11-06       Impact factor: 4.530

5.  Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake.

Authors:  Vez Repunte-Canonigo; Lena D van der Stap; Jihuan Chen; Valentina Sabino; Ulrich Wagner; Eric P Zorrilla; Gunter Schumann; Amanda J Roberts; Pietro Paolo Sanna
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6.  PI3K activation within ventromedial prefrontal cortex regulates the expression of drug-seeking in two rodent species.

Authors:  Karen K Szumlinski; Alexis W Ary; Christina B Shin; Melissa G Wroten; Justin Courson; Bailey W Miller; Micaela Ruppert-Majer; John W Hiller; John R Shahin; Osnat Ben-Shahar; Tod E Kippin
Journal:  Addict Biol       Date:  2018-11-18       Impact factor: 4.280

7.  Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine.

Authors:  Sergio D Iñiguez; Brandon L Warren; Rachael L Neve; Eric J Nestler; Scott J Russo; Carlos A Bolaños-Guzmán
Journal:  Behav Neurosci       Date:  2008-10       Impact factor: 1.912

8.  Cocaine regulates MEF2 to control synaptic and behavioral plasticity.

Authors:  Suprabha Pulipparacharuvil; William Renthal; Carly F Hale; Makoto Taniguchi; Guanghua Xiao; Arvind Kumar; Scott J Russo; Devanjan Sikder; Colleen M Dewey; Maya M Davis; Paul Greengard; Angus C Nairn; Eric J Nestler; Christopher W Cowan
Journal:  Neuron       Date:  2008-08-28       Impact factor: 17.173

Review 9.  Insulin, leptin and reward.

Authors:  Jon F Davis; Derrick L Choi; Stephen C Benoit
Journal:  Trends Endocrinol Metab       Date:  2009-10-07       Impact factor: 12.015

Review 10.  Brain-derived neurotrophic factor and cocaine addiction.

Authors:  Jacqueline F McGinty; Timothy W Whitfield; William J Berglind
Journal:  Brain Res       Date:  2009-09-02       Impact factor: 3.252
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